mIDH1-targeted RNA Modification and Metabolomics Analysis Tool

CAT#: ITS-0524-CR2
Cell Type: M1 macrophages
RNA writers: METTL14
RNA readers: YTHDF2
RNA erasers: ALKBH5
Enzymes: HDACs
RNA types: tRNA
Modification: ψ
RNA editing: A to I
Short Description
This product is a mIDH1-targeted RNA modification and metabolomics analysis tool based on the ψ (METTL14-YTHDF2-ALKBH5-HDACs-DBCO) modification and TCA cycle-mediated (RBFOX1-SAM-ATP) metabolic analysis system.
RNA writers
METTL14
RNA readers
YTHDF2
RNA erasers
ALKBH5
Enzymes
HDACs
RNA types
tRNA
Modification
ψ
Label
DBCO
RNA editing
A to I
Cell Type
M1 macrophages
Oligonucleotide
2'-OMe (cationic lipoplex)
RNA Construction
tRNA-ψ-METTL14-YTHDF2-ALKBH5-HDACs-DBCO
Substrates
SAM
Cofactors
ATP
Pathway
TCA cycle
Epigenetic regulator
EZH2 deficiency
Metabolic alteration
Activating branched-chain amino acidsmetabolism
Targeting diseases
Acute Myeloid Leukemia
RNA-binding proteins
RBFOX1
Metabolic Reprogramming
TCA cycle-RBFOX1-SAM-ATP
Target
mIDH1
Alternative Names
IDH1; HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD; isocitrate dehydrogenase (NADP(+)) 1; cytosolic; isocitrate dehydrogenase (NADP(+)) 1
Format
Liquid
Shipping
All ordered products are shipped from Fedex or UPS.
Handling Advice
Prevent prolonged exposure to light.
Storage
Recommended long-term storage in - 20 ° C, to ensure the longest shelf life of products.
For Research Use Only | Not For Clinical Use
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