ModifiSite™ Alanine Transaminase Assay Kit

CAT#: ITS-1125-HM7
Product Type: Assay Kit
Species: All Species
Short Description
Quantifies ALT activity, a primary biomarker for liver damage.
Brand
ModifiSite
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Alanine Transaminase Assay Kit serves as a primary biomarker for hepatocellular injury, making it indispensable for assessing drug-induced liver injury (DILI) during pre-clinical toxicology. This kinetic assay enables the continuous monitoring of enzyme activity, providing real-time data on the hepatotoxic potential of new chemical entities. Its implementation in safety screening protocols helps reduce late-stage attrition by identifying liver toxicity early in the development process.
Features
Kinetic assay design enables continuous monitoring of enzyme activity; Critical for early-stage hepatotoxicity screening in pre-clinical safety panels.
Process Relevance
Hepatotoxicity Screening (DILI)
Application Stage
Pre-clinical Safety
Applications
Standard assay for hepatotoxicity studies and monitoring liver health.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 340 nm
Sample Type
Serum, plasma samples
Research Areas
Hepatology; Toxicology
Size
100 tests
Data Output Type
Kinetic (Enzyme Activity)
Assay Time
Results in 10 min
LOD
2 U/L
Species
All Species
Storage
Store at −20 °C upon receipt to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. During use, minimize the time components are exposed to room temperature and return them promptly to −20 °C storage after handling. Do not store at elevated temperatures for extended periods.
Expiry Date
6 months under recommended storage conditions to ensure optimal performance.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
Alanine Transaminase (ALT) catalyzes the transfer of an amino group from alanine to alpha-ketoglutarate. Predominantly found in the liver its release into the bloodstream is a specific and sensitive indicator of hepatocellular injury and liver disease.
For Research Use Only | Not For Clinical Use
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