Short Description
Determines ALDH enzyme activity, crucial for alcohol metabolism.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Aldehyde Dehydrogenase Assay Kit validates the activity of critical detoxification enzymes, which is essential for developing therapies for alcohol dependence and oxidative stress disorders. By quantifying ALDH activity, researchers can assess the efficacy of drugs designed to mitigate aldehyde-induced cellular damage. This robust protocol is suitable for automated systems, facilitating high-throughput screening of compounds that modulate detoxification pathways.
Features
Fast and robust protocol suitable for automated systems; Validates ALDH activity modulation in oxidative stress and addiction therapy research.
Process Relevance
Oxidative Stress & Detoxification
Application Stage
ADME / DMPK
Applications
Investigates oxidative stress responses and alcohol metabolism pathways.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 565 nm
Sample Type
Serum, citrate-plasma, urine, cell lysate, culture medium
Research Areas
Toxicology; Oxidative Stress
Datasheet