ModifiSite™ Angiotensin-Converting Enzyme 1 Assay Kit

CAT#: ITS-1125-HM101
Product Type: Assay Kit
Species: All Species
Brand: ModifiSite
Development Stage: Research-Grade Protein & Enzyme Assay Development
Short Description
Measures ACE1 activity using a fluorometric substrate.
Brand
ModifiSite
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Angiotensin-Converting Enzyme 1 Assay Kit uses a FRET-peptide substrate for the high-throughput screening of ACE inhibitors, a primary class of antihypertensive drugs. This assay validates the potency of compounds targeting the renin-angiotensin system, supporting cardiovascular drug discovery. It provides kinetic data for characterizing enzyme inhibition and optimizing lead candidates for blood pressure control.
Features
FRET-peptide substrate; High-throughput screening of ACE inhibitors for hypertension control.
Process Relevance
Cardiovascular Drug Discovery
Application Stage
Hit-to-Lead Screening
Applications
Hypertension research and ACE inhibitor screening.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Fluorescence Detection (Ex 360 nm / Em 485 nm)
Sample Type
Serum, cell or tissue lysate, and other biological samples
Research Areas
Cardiovascular Disease
Size
100 tests
Data Output Type
Kinetic (Enzyme Activity)
Assay Time
Results in 45 min
LOD
0.01 U/L
Species
All Species
Storage
Store at −20 °C upon receipt to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. During use, minimize the time components are exposed to room temperature and return them promptly to −20 °C storage after handling. Do not store at elevated temperatures for extended periods.
Expiry Date
6 months under recommended storage conditions to ensure optimal performance.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
Angiotensin-Converting Enzyme (ACE) regulates blood pressure by producing angiotensin II. ACE inhibitors are standard hypertension therapy; measuring ACE activity monitors the renin-angiotensin system.
For Research Use Only | Not For Clinical Use
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