Short Description
Measures ACE1 activity using a fluorometric substrate.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Angiotensin-Converting Enzyme 1 Assay Kit uses a FRET-peptide substrate for the high-throughput screening of ACE inhibitors, a primary class of antihypertensive drugs. This assay validates the potency of compounds targeting the renin-angiotensin system, supporting cardiovascular drug discovery. It provides kinetic data for characterizing enzyme inhibition and optimizing lead candidates for blood pressure control.
Features
FRET-peptide substrate; High-throughput screening of ACE inhibitors for hypertension control.
Process Relevance
Cardiovascular Drug Discovery
Application Stage
Hit-to-Lead Screening
Applications
Hypertension research and ACE inhibitor screening.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Fluorescence Detection (Ex 360 nm / Em 485 nm)
Sample Type
Serum, cell or tissue lysate, and other biological samples
Research Areas
Cardiovascular Disease
Datasheet