Short Description
Measures arginase activity by detecting urea production.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Arginase Assay Kit utilizes a urea-based detection method to validate arginase inhibitors for cancer immunotherapy and cardiovascular disease applications. This assay supports research into the regulation of the urea cycle and immune suppression in the tumor microenvironment. By avoiding radioactive isotopes, it provides a safe and efficient means to screen modulators of arginine metabolism.
Features
Urea-based detection avoids radioactive isotopes; Validates arginase inhibitors for cancer immunotherapy and cardiovascular disease.
Process Relevance
Immuno-Oncology (Tumor Microenvironment)
Application Stage
Lead Optimization
Applications
Investigating urea cycle disorders and immune regulation.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 430 nm
Sample Type
Enzyme preparations, serum, plasma, tissue culture samples
Research Areas
Immuno-Oncology; Cardiovascular Disease
Datasheet