Short Description
Quantifies farnesyltransferase activity.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Farnesyltransferase Activity Assay Kit uses fluorometric peptide labeling to screen FTase inhibitors, aiming to block Ras signaling in cancer. This assay validates drugs that prevent the membrane localization of oncogenic proteins. It supports the development of targeted cancer therapies by quantifying the activity of the prenylation machinery.
Features
Fluorometric peptide labeling; Screening FTase inhibitors to block Ras signaling in cancer.
Process Relevance
Ras Signaling Inhibition
Application Stage
Lead Optimization
Applications
Ras protein modification and cancer therapy research.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Fluorescence Detection (Ex 340 nm / Em 550 nm)
Sample Type
Serum, citrate-plasma, urine, cell lysate, culture medium, purified enzyme
Datasheet