Short Description
Quantifies SDH activity via NADH production.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Sorbitol Dehydrogenase Assay Kit measures the conversion of sorbitol to fructose, assessing polyol pathway activity in diabetic neuropathy research. This assay validates inhibitors of the sorbitol pathway, which is implicated in tissue damage from hyperglycemia. It supports the study of diabetic complications and fructose metabolism in liver and kidney tissue.
Features
Measures conversion of sorbitol to fructose; Assessing polyol pathway activity in diabetic neuropathy.
Process Relevance
Diabetic Complications Research
Application Stage
Discovery
Applications
Diabetic complications (polyol pathway) research.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 565 nm
Sample Type
Serum, citrate-plasma, urine, cell lysate, culture medium
Research Areas
Diabetes (Complications)
Datasheet