NCI-H441 In Vitro Reactive Oxygen Species Assay (Oxidative Stress)

This assay is to provide NCI-H441-based In Vitro Reactive Oxygen Species Assay (Oxidative Stress) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

NCI-H441

Human

NCI-H441 [H441] cells were isolated in 1982 from the pericardial fluid of a male patient with papillary adenocarcinoma of the lung. Use these cells as a transfection host for expression of pulmonary surfactant protein (SP-B).

H441

Lung Cancer

Oncology

In Vitro Reactive Oxygen Species Assay (Oxidative Stress)

Oxidative Stress Assays

Disturbance between the production of reactive oxygen species (ROS), free radicals and antioxidant mechanisms is defined as the oxidative stress, or more precisely, it is an imbalance between the oxidant and antioxidant state in cells. This imbalance can cause harmful effects to cells and biomolecules, which ultimately causes adverse effects in the whole organism. Oxidative imbalance can target important proteinsand lipids in cells, which can increase the risk of developing a cancer. On the other hand, increased ROS production in cancer cells by certain cancer drugs can also arrest cancer cell cycle and cause senescence and apoptosis through oxidative stress.

Markers Thiobarbituric Acid Reactive Substances