OCI-Ly3 In Vitro TRAP Assay (Senescence)

This assay is to provide OCI-Ly3-based In Vitro TRAP Assay (Senescence) to accelerate our client's oncology projects. The assay will be customized according to the specific requirements. Please contact our scientists to discuss more details.

OCI-Ly3

Human

Human B-cell non-Hodgkin lymphoma cell line established in 1983 from the bone marrow sample of a 52-year-old man with B-cell non-Hodgkin lymphoma

Lymphoma

Oncology

In Vitro TRAP Assay (Senescence)

The telomerase repeated amplification protocol (TRAP) assay is one of the common PCR-based assays used to detect telomerase activity in cells.

Telomerase Repeated Amplification Protocol Assay

Cellular Senescence in Cancer Assays

Cell senescence is described as an irreversible physiological event of cell growth arrest, which is known to be caused by alterations of telomeres, oxidative stress, DNA damage and some oncogenes. Inhibition of the program of senescence is one of the main features of tumor cells and it has been reported that cancer cells can be induced to undergo senescence by chemo- and radiotherapies and genetic alterations. Telomeres help to prevent uncontrolled cell proliferation and the absence of telomeres results in aneuploidy and cell death.

TRAP Assay