OncoIHC™ CYP3A4 Ready-To-Use IHC Kit

Facilitate CYP3A4 detection using this ready-to-deploy IHC solution, encompassing all necessary reagents from antigen retrieval to slide preparation.

Cytochrome P450 3A (CYP3A) enzymes are essential in the detoxification of xenobiotics and the metabolism of over half of all pharmaceuticals. CYP3A activity influences drug absorption and clearance, with expression levels varying across tissues like the liver, intestine, kidney, and brain. In response to systemic infections, such as lipopolysaccharide (LPS) exposure, CYP3A expression can be downregulated, particularly in the liver, affecting drug metabolism.

Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining

IHC

CYP3A4

Human

Immunohistochemistry

FFPE tissue

Primary Antibody
Secondary Antibody
Antigen Unmasking Buffer
Washing Buffer
Blocking Buffer
Color Development Reagent 1
Color Development Reagent 181
Signal Amplification Reagent
Contrast Staining Agent
Preservation Matrix

To ensure the preservation of their functional properties, all reagents within this kit must be maintained at a temperature between 2°C and 8°C. Under these storage conditions, the kit will retain its effectiveness for a period of 6 to 12 months following receipt.

Albendazole monooxygenase; Albendazole sulfoxidase; CP33; CP34; CYP3A; CYP3A3; CYP3A4; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 3A4; Cytochrome P450 HLp; Cytochrome P450 NF 25; Cytochrome P450 PCN1; HLP; NF25; Nifedipine oxidase; P450C3; P450PCN1; Quinine 3 monooxygenase

Creative Biolabs control slides are prepared using top quality tissues that have been processed, embedded and sectioned following standard operating procedure. We provide the following antigen (tissue) controls:
- Positive control: a section from a tissue known to express the protein of interest.
- Negative control: a section from a tissue known not to express the target antigen.
- Endogenous tissue background control: a section from the tissue that doesn't have a primary antibody applied.

Creative Biolabs also offers biospecimen including formalin fixed paraffin embedded (FFPE) tissue blocks, fresh or snap frozen tissue blocks, tissue microarray (TMA) slides. Please contact us to request a customized price quotation.

Tissue Fixative Solution (Specified, depends on antigen type and tissue source)
Tissue Processing Kit (Includes specialized media for tissue collection, isolation, and dissociation)
Tissue Embedding Media
Tissue Staining Kit (Optional)