Short Description
Achieve efficient DSG1 staining with this comprehensive IHC kit, pre-loaded with reagents for a seamless antigen retrieval to coverslip process.
Description
Desmosomes are specialized cell-cell junctions found in tissues like the epidermis and myocardium. These junctions are mediated by desmosomal cadherins, including desmogleins (DSG1-4) and desmocollins (DSC1-3), which facilitate calcium-dependent adhesion. DSG1 plays a vital role in epidermal barrier function and cell differentiation, with mutations linked to skin disorders such as striate palmoplantar keratoderma and SAM syndrome, a condition involving dermatitis and metabolic issues.
Features
Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining
Analytical Method
Immunohistochemistry
Datasheet