OncoIHC™ TDP-43 Ready-To-Use IHC Kit

For the effective localization of TDP43, this integrated IHC kit delivers a complete solution. Its ready-to-apply reagents, covering all stages from antigen retrieval to slide preparation, streamline the workflow, enabling researchers to obtain accurate and reproducible IHC results.

The TARDBP gene encodes TDP-43, a protein initially identified as a repressor of HIV-1 transcription by binding TAR DNA. TDP-43 also binds RNA and plays a role in transcriptional repression, translational regulation, and pre-mRNA splicing, including the regulation of CFTR gene splicing. Hyperphosphorylated, ubiquitinated, and cleaved forms of TDP-43, known as pathological TDP-43, are implicated in diseases like ALS and FTLD-U. Recently, TDP-43 has been linked to triple-negative breast cancer (TNBC) and may serve as a target for diagnosis and drug design.

Ready to use
High Sensitivity Streptavidin (HSS) increases detection sensitivity
Suitable for tissue sections & cytospin preparations
Pre-diluted reagents minimize hands-on time
Optimizes mouse, rabbit, rat, goat, or sheep IgG primary antibody staining

IHC

TDP-43

Human, Mouse, Rat

Immunohistochemistry

FFPE tissue

Primary Antibody
Secondary Antibody
Antigen Unmasking Buffer
Washing Buffer
Blocking Buffer
Color Development Reagent 1
Color Development Reagent 5
Signal Amplification Reagent
Contrast Staining Agent
Preservation Matrix

To ensure the preservation of their functional properties, all reagents within this kit must be maintained at a temperature between 2°C and 8°C. Under these storage conditions, the kit will retain its effectiveness for a period of 6 to 12 months following receipt.

ALS10; TAR DNA binding protein; TAR DNA binding protein 43; TARDBP; TDP43; tdp-43

Creative Biolabs control slides are prepared using top quality tissues that have been processed, embedded and sectioned following standard operating procedure. We provide the following antigen (tissue) controls:
- Positive control: a section from a tissue known to express the protein of interest.
- Negative control: a section from a tissue known not to express the target antigen.
- Endogenous tissue background control: a section from the tissue that doesn't have a primary antibody applied.

Creative Biolabs also offers biospecimen including formalin fixed paraffin embedded (FFPE) tissue blocks, fresh or snap frozen tissue blocks, tissue microarray (TMA) slides. Please contact us to request a customized price quotation.

Tissue Fixative Solution (Specified, depends on antigen type and tissue source)
Tissue Processing Kit (Includes specialized media for tissue collection, isolation, and dissociation)
Tissue Embedding Media
Tissue Staining Kit (Optional)