Short Description
Quantifies G6PDH activity via NADPH generation.
Development Stage
Research-Grade Metabolic Assay Development
Description
The OXPHOSight™ Glucose-6-Phosphate Dehydrogenase Kit is a homogeneous screening tool for identifying G6PD deficiency liabilities, crucial for the safety of antimalarial and oxidant drugs. This assay supports pharmacogenetic research by characterizing enzyme activity in patient samples. It is essential for pre-clinical safety assessments to prevent drug-induced hemolysis in susceptible populations.
Features
Homogeneous colorimetric assay; Screening for G6PD deficiency liabilities in antimalarial drug development.
Process Relevance
Pharmacogenetics (Hemolysis Risk)
Application Stage
Pre-clinical Safety
Applications
Screening for G6PD deficiency and hemolytic anemia risk.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 565 nm
Sample Type
Plasma, serum, tissue and culture media, samples
Research Areas
Hematology; Genetic Disorders
Datasheet