P450-Metric™ Cytochrome P450 26A1 (CYP26A1) ELISA Kit

CAT#: ITS-0326-YL14
Product Type: Assay Kit
Species: Human
Brand: P450-Metric™
Development Stage: ADME
ADME Research Domain: Metabolism
Short Description
Quantifies CYP26A1 using a double-antibody sandwich ELISA.
Brand
P450-Metric™
Development Stage
ADME
ADME Research Domain
Metabolism
Description
This robust double-antibody sandwich ELISA kit is engineered to deliver highly precise quantitative measurement of Cytochrome P450 26A1 across various biological samples. Ensuring excellent intra-assay reliability and rigorous target specificity, this research-use-only platform facilitates detailed investigations into hepatic retinoic acid clearance. It functions as an indispensable laboratory asset for evaluating the pharmacokinetics of retinoid-based therapeutics and related drug-drug interactions in early-stage preclinical ADME profiling.
Features
Delivering excellent analytical specificity, this quantitative ELISA accurately measures CYP26A1, providing an essential analytical platform for studying retinoic acid clearance and related drug-drug interactions.
Process Relevance
Measuring CYP26A1 to characterize systemic pharmacokinetics and potential metabolic induction of synthetic retinoid therapeutics.
Application Stage
Preclinical drug discovery, ADME profiling, and pharmacokinetic research
Applications
Employ this reliable sandwich ELISA to accurately measure target enzyme concentrations in tissue homogenates and biological fluids.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Sample Type
Serum, plasma, tissue homogenates, cell lysates
Research Areas
ADME; Drug Metabolism; Pharmacokinetics; Toxicology
Size
48 / 96 tests
Data Output Type
Absorbance (OD)
LOD
Human: 0.061 ng/mL
Species
Human
Storage
Upon receipt, please follow the storage recommendations in the USER MANUAL to maintain reagent stability. Follow recommended handling procedures to ensure consistent assay performance.
Storage Comment
Avoid repeated freeze-thaw cycles. Do not store at elevated temperatures for extended periods.
Note
For bulk pricing or custom reagent inquiries, please contact us by email or phone. Products are shipped on ice via FedEx.
Restrictions
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Shipping
Shipped on ice under temperature-controlled conditions.
Background
Cytochrome P450 26A1 is the primary hepatic enzyme tasked with the targeted metabolic inactivation and clearance of all-trans-retinoic acid. Accurately profiling its activity is crucial for understanding the systemic pharmacokinetics of retinoid-based therapeutics and predicting potential teratogenic liabilities.
For Research Use Only | Not For Clinical Use
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