Pan-Cancer based Metastatic Tumor Microbiome Analysis Service
Background Service What we can offer Workflow Highlights FAQs Contact
Are you currently facing challenges in understanding the mechanisms behind treatment resistance and metastatic disease progression? Creative Biolabs' pan-cancer-based metastatic tumor microbiome analysis service helps you uncover novel therapeutic targets and biomarkers by providing a comprehensive, multi-domain view of the microbial landscape in metastatic tumors through advanced sequencing and multi-omics data integration.
Introduction
Tumors are home to a diverse and clinically significant microbial community. These microbial residents are not passive bystanders; they are actively influenced by host genetics and, in turn, play a pivotal role in shaping the tumor's immune response, driving metastatic progression, and mediating resistance to cutting-edge therapies like immune checkpoint blockade. Pan-cancer microbiome studies, spanning various cancer types and distinct samples, rapidly chart universal yet cancer-type-specific landscapes of tumor-resident bacteria and fungi, moving beyond single-tumor paradigms, which is useful for illuminating potential mechanisms of immune evasion and metastatic colonization.
Fig.1 The atlas of pan-cancer microbiome.1
Pan-cancer-based Metastatic Tumor Microbiome Analysis Services at Creative Biolabs
Creative Biolabs' pan-cancer based metastatic tumor microbiome analysis service offers a comprehensive solution to elucidate the intricate microbial communities within metastatic tumors. By analyzing the pan-cancer landscape of the metastatic microbiome, encompassing bacteria, fungi, and viruses, we provide actionable insights that facilitate the identification of novel biomarkers for patient prognosis and enable stratification of patients based on their likelihood of responding to specific therapies, such as immune checkpoint blockade.
What We Can Offer?
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We provide a comprehensive and multi-domain analysis of the tumor microbiome, meticulously profiling bacteria, fungi, and viruses within a single project.
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We have advanced computational pipelines and robust decontamination methods, which ensures the reality and clinically relevance of the microbial signatures.
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We specialize in integrating microbial data with host genomics, transcriptomics, and immune cell profiling, accelerating you to uncover the complex interplay between the host and the microbiome.
Our Service Process
Our streamlined and rigorous workflow ensures high-quality, reliable results tailored to your specific project needs.
Required Materials:
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Metastatic Tumor Biopsy Samples
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Associated Clinical Data
Key Steps in service process:
Key Advantages
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Actionable and Prognostic Data: We provide not only raw data but also actionable insights, including the identification of specific prognostic biomarkers and a deeper understanding of molecular pathways.
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Expert Consultation and Support: Our team of experienced experts is available to provide expert guidance at every stage of your project, from experimental design to data interpretation.
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Precision for Metastatic Cancer Research: Our workflow is meticulously optimized to address the unique complexities inherent in analyzing metastatic samples, thereby enabling you to unlock unparalleled insights into the intricate dynamics of advanced-stage disease progression.
FAQs
Q1: How do you distinguish between genuine tumor microbes and contamination?
A1: Our service employs a proprietary computational pipeline, which does well in filtering out environmental and reagent contaminants validated by published data. This rigorous decontamination process ensures the reliability of the microbial signatures.
Q2: Is your service suitable for analyzing metastatic tumor samples?
A2: Yes, our service is specifically tailored for this purpose. Microbial communities in metastatic lesions are associated with organ-specific tropism and treatment resistance. Our workflow is optimized to analyze these challenging samples, providing valuable insights into disease progression.
Q3: What are the key advantages of your service compared to others?
A3: Our primary advantage lies in our integrated, multi-domain approach. We offer a comprehensive profiling of distinct microbiome, and seamlessly integrate data with host genomics and immune profiles, which ensures unparalleled depth and reliability of the results.
Why Choose Us?
Creative Biolabs is your reliable partner for exploring microbiome in metastatic tumors. Our pan-cancer based metastatic tumor microbiome analysis service provide comprehensive, multi-domain approaches and integrate microbial data with host genetics and immune system profiles, which is meaningful for mechanistic exploration.
Customer Reviews
" The patient stratification capabilities of our research team were substantially enhanced through the utilization of Creative Biolabs Pan-cancer based Metastatic Tumor Microbiome Analysis Service. The provision of multi-domain data provided a granular level of detail that was unattainable with conventional 16S rRNA gene sequencing. " J. B***r, Research Director.
"The integration of host genetic data with the microbial profiles furnished by Creative Biolabs was transformative for our research. This synthesis of multi-omics data facilitated a progression beyond mere correlational observations, permitting a deeper inquiry into the underlying biological mechanisms governing heterogeneous patient responses to treatment. " Dr. D. P***s, Oncology Team Lead.
"The analytical service provided by Creative Biolabs yielded the profound mechanistic insights that our project required. Their comprehensive report, which detailed how a specific bacterial species may influence a key cellular signaling pathway, represents a significant finding. The multi-omics dataset was robust and systematically structured, enabling our team to rapidly validate the reported results and to identify a promising new therapeutic target. " S. A***n, Senior Scientist.
How to Contact Us?
To discuss your project in detail and discover how our service can provide the insights you need, please reach out to our team of experts.
Contact us for more information and to discuss your project.
Reference
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Narunsky-Haziza, Lian et al. "Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions." Cell vol. 185,20 (2022): 3789-3806.e17. Distributed under Open Access License CC BY 4.0, without modification. DOI: https://doi.org/10.1016/j.cell.2022.09.005
