Next-IO™ PAUF Therapeutic Monoclonal Antibody Program

About This Program

This program aims to develop PAUF therapeutic monoclonal antibody for pancreatic cancer immunotherapy.

Rationale for our program:

These findings indicate an important role for PAUF in pancreatic cancer progression and metastasis.

PAUF

Pancreatic cancer up-regulation factor (PAUF), also known as ZG16B, was first discovered in secreted Pancreatic cancer cell secreted proteins. PAUF is highly expressed in many cancers, such as pancreatic cancer, cervical cancer, and ovarian cancer. In particular, in pancreatic cancer, PAUF promotes adhesion and enhanced the resistance of pancreatic cancer cells to anoikis by modulating Focal Adhesion kinase. PAUF interacts with the Toll-like receptor (TLR2 / 4) to activate CXCR4 and promote angiogenesis.

PAUF enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer. Fig.1 PAUF enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer. (Thyagarajan, 2019)

Recent studies have shown that:

(Cho, 2017)

This data supports the rationale for the development of the first-in-class human PAUF Abs with an improved therapeutic index for the treatment of pancreatic cancer.

Pancreatic Cancer

Ongoing Clinical Trials

Program Plan

We have extensive knowledge of end-to-end program development. For each program, we are committed to delivering the final complete program to our clients within 1.5 years before entering the IND stage.

Cooperation

Creative Biolabs is looking for potential partners (include but not limit to major pharma or biotech firms) to develop PAUF therapeutic monoclonal antibody program together. Our scientists are dedicated to bringing years of valuable experience to our partner and achieve a meaningful partnership together. For any partners interested in our Next-IO™ programs, Creative Biolabs welcomes collaboration.

Here are two ways for your choice, and please contact us for more details.

1) Collaborate with us and co-develop the programs from the discovery phase to IND enabling. Costs will be shared.

2) Become a licensed candidate for our programs.

With our quality control protocol and knowledge of global regulatory requirements, we can help our partners further their programs with more chances to succeed. Look forward to cooperating with you in the near future.

References

For Research Use Only | Not For Clinical Use

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