Phorbol 12-myristate 13-acetate (PMA) (CAT#: ITS-0622-YT341)

Phorbol 12-myristate 13-acetate, a phorbol ester, is a reversible, highly potent activator of protein kinase C (PKC). It works as a tumor promoter and is involved in gene transcription, cell growth, differentiation, programmed cell death, immune pathway and receptor desensitization via PKC signaling pathways. It can also induce differentiation of THP-1 monocytes to a macrophage phenotype in vitro.

Differentiation

1mg; 5mg

Phorbol 12-myristate 13-acetate;12-O-Tetradecanoylphorbol-13-acetate; PMA; TPA

Cancer Cells and Cell Lines, Mesenchymal Stem and Progenitor Cells, Monocytes, T Cells

Human, Mouse, Rat, Non-Human Primate, Other

PKC

Protein kinase C (PKC)

Stem Cell Biology

Restrictions for research use only. Intended for use by laboratory professionals.