SDHB-targeted RNA Modification and Metabolomics Analysis Tool

CAT#: ITS-0524-CR44
Cell Type: M1 macrophages
RNA writers: NSUN1
RNA readers: ALYREF
RNA erasers: ALKBH1
Enzymes: NNMT
RNA types: mRNAs
Modification: ac4C
RNA editing: T to C
Short Description
This product is a SDHB-targeted RNA modification and metabolomics analysis tool based on the ac4C (NSUN1-ALYREF-ALKBH1-NNMT-spacer C9) modification and Mevalonate pathway-mediated (α-synuclein-Lactyl-CoA-ADP) metabolic analysis system.
RNA writers
NSUN1
RNA readers
ALYREF
RNA erasers
ALKBH1
Enzymes
NNMT
RNA types
mRNAs
Modification
ac4C
Label
spacer C9
RNA editing
T to C
Cell Type
M1 macrophages
Oligonucleotide
PS, 2'-OMe, 2'-F, GalNAc
RNA Construction
mRNAs-ac4C-NSUN1-ALYREF-ALKBH1-NNMT-spacer C9
Substrates
Lactyl-CoA
Cofactors
ADP
Pathway
Mevalonate pathway
Epigenetic regulator
SMARCA4 deficiency
Metabolic alteration
Upregulating oxidative phosphorylation
Targeting diseases
Esophageal Cancers
RNA-binding proteins
α-synuclein
Metabolic Reprogramming
Mevalonate pathway-α-synuclein-Lactyl-CoA-ADP
Target
SDHB
Alternative Names
SDHB; CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP; succinate dehydrogenase complex iron sulfur subunit B; MC2DN4
Gene ID
6390(Human); 67680(Mouse); 298596(Rat)
UniProt ID
P21912(Human); Q9CQA3(Mouse); P21913(Rat)
Format
Liquid
Shipping
All ordered products are shipped from Fedex or UPS.
Handling Advice
Prevent prolonged exposure to light.
Storage
Recommended long-term storage in - 20 ° C, to ensure the longest shelf life of products.
For Research Use Only | Not For Clinical Use
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