TIGAR-targeted RNA Modification and Metabolomics Analysis Tool

CAT#: ITS-0524-CR61
Cell Type: M2 macrophages
RNA writers: METTL14
RNA readers: YTHDF2
RNA erasers: ALKBH5
Enzymes: PHGDH
RNA types: mRNAs
Modification: m5C
RNA editing: C to U
Short Description
This product is a TIGAR-targeted RNA modification and metabolomics analysis tool based on the m5C (METTL14-YTHDF2-ALKBH5-PHGDH-spacer C9) modification and Mevalonate pathway-mediated (CPEB4-Acetyl-CoA-ATP) metabolic analysis system.
RNA writers
METTL14
RNA readers
YTHDF2
RNA erasers
ALKBH5
Enzymes
PHGDH
RNA types
mRNAs
Modification
m5C
Label
spacer C9
RNA editing
C to U
Cell Type
M2 macrophages
Oligonucleotide
2'-MOE
RNA Construction
mRNAs-m5C-METTL14-YTHDF2-ALKBH5-PHGDH-spacer C9
Substrates
Acetyl-CoA
Cofactors
ATP
Pathway
Mevalonate pathway
Epigenetic regulator
ARID1A deficiency
Metabolic alteration
Inhibiting reduced glutathione synthesis
Targeting diseases
Lung Cancer
RNA-binding proteins
CPEB4
Metabolic Reprogramming
Mevalonate pathway-CPEB4-Acetyl-CoA-ATP
Target
TIGAR
Alternative Names
TIGAR; FR2BP; C12orf5; TP53 induced glycolysis regulatory phosphatase
Format
Liquid
Shipping
All ordered products are shipped from Fedex or UPS.
Handling Advice
Prevent prolonged exposure to light.
Storage
Recommended long-term storage in - 20 ° C, to ensure the longest shelf life of products.
For Research Use Only | Not For Clinical Use
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