Tumor Cellular Metabolism Assay Services

Metabolism: An Entry Point for Cancer Research

Cellular metabolism has recently been revealed as an essential factor in tumor cell proliferation. Tumor cells undergo considerable metabolic adaption modifications, known as metabolic reprogramming, to generate more energy to fulfill increased demands for ATP, NAD(P)H, and carbon skeletons. Metabolic reprogramming has substantial impacts, but its mechanisms and consequences are just now becoming understood. Therefore, it is necessary to establish tumor cellular metabolism assay services platforms to further the understanding of metabolic reprogramming and facilitate the development of cancer therapies.

Fig.1 Cellular metabolic crosstalk in the TME.¹

Distinctive Characteristics of Cell Cancerization

Infinite capacity for reproduction	Insufficient sensitivity to growth-inhibiting stimuli
Continual angiogenesis	Invading and spreading to other tissues
The suppression of programmed cell death	Defense against the immune system
Autonomy in growth signals	Energy metabolism reprogramming

Our Tumor Cellular Metabolism Assay Services

Creative Biolabs developed a range of tumor cellular metabolism assay services to support global customers' projects and aid in the development of cancer therapy. Our tumor intracellular metabolism services are designed to target various aspects of tumor cell metabolism. We utilize the principle of metabolism-related oxidative phosphorylation coupling luciferase reactions to accurately measure changes in the levels of corresponding aspects. This allows us to effectively assess the metabolic levels within tumor cells. In addition, we can customize the assay services to enable desirable high-quality outcomes for global customers. Specifically, we can provide tumor cellular metabolism assay services as follows for global customers' convenience:

Fig.2 Tumor cellular metabolic signaling pathways.²

Benefits for You

Benefits. (Creative Biolabs Original)

High-sensitive, high reproducibility, and sustained stability to enable high-quality outcomes presentation.
Rigorous quality control to guarantee the smooth operation of the entire project.
Professional research team to guarantee smooth project execution from conception to finish, lowering the likelihood of mistakes.
Comprehensive customized services to fulfill the diverse demands of global customers.

Q & A

Q1: What do tumor metabolic assays measure?

A1: Metabolic assays are used to determine metabolic stability in chemical structures related to tumor metabolism. We may test the enzymes or molecules related to the tumor metabolic pathway using our tumor cellular metabolism assay services. Amino acids and glucose are also important for tumor metabolism, which is also a focus for our tumor cellular metabolism assay services. Furthermore, the metabolite is an essential marker that directly reflects the cellular metabolism of the tumor. More research is ongoing, and we are continuously studying fresh techniques to help in the development of cancer treatment.

Q2: How do measure metabolism in a tumor cell?

A2: We employ the principle of coupling luciferase reactions to metabolism-related redox reactions to accurately measure changes in the levels of corresponding aspects.

Work with Creative Biolabs

Contact flowchart. (Creative Biolabs Original)

Here, we provide a simple inquiry mode for your convenience. Please don't hesitate to get in touch with us to learn more details about our tumor cellular metabolism assay services. We are looking forward to receiving your inquiry.

References

Martínez-Reyes, Inmaculada, and Navdeep S. Chandel. "Cancer metabolism: looking forward." Nature Reviews Cancer 21.10 (2021): 669-680.
DeBerardinis, Ralph J., and Navdeep S. Chandel. "Fundamentals of cancer metabolism." Science Advances 2.5 (2016): e1600200.

For Research Use Only | Not For Clinical Use