Banner: A Man Is Doing Experiments for Tumor Marker Assay. (Creative Biolabs Authorized)

Different Types of Tumor Markers

Tumor markers are proteins or other substances found in or released by cancer cells or other body cells during an attack of cancer or benign (noncancerous) conditions. It might tell us something about cancer, like its virulence, which can also open the door to many new ways for scientists to treat tumors. With its in-house scientists and innovative technological platforms, Creative Biolabs is certain to deliver tumor marker assays that enable your project to become a reality.

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Tumor Marker Detection. (Creative Biolabs Authorized)

Why to Detect Tumor Marker?

Tumor markers are essential in immuno-oncology. They allow scientists to assess immune responses and immune escape routes in the tumor microenvironment, thereby defining targets for immunotherapeutic cancer therapies. Cancer markers like PD-L1, CTLA-4, and others involved with immune checkpoints are key to developing immunotherapies that regulate the immune response to cancer. With practical knowledge, tumor marker assays help to push immuno-oncology toward better and more individualized treatments for patients.

Creative Biolabs is the expert in precise tumor marker assays backed by in-house science and state-of-the-art technology. With more than 20 years in the business, we bring industry expertise to the table by offering specific assay solutions for a variety of cancer studies. With our robust platforms and skilled staff, we make sure each assay is scientifically proven and yields reproducible, repeatable results for important cancer research.

Different Types of Tumor Markers

Creative Biolabs has an array of tumor markers stratified by cancer, further optimizing the sensitivity and power of your research. This portfolio contains markers for different types of cancer:

Cancer Type	Tumor Markers
Bladder Cancer	EpCAM, FGFR3, VEGF-A, CD47, CD73
Brain Cancer	EGFR, CD44v6, STAT3, MGMT, IDH1
Breast Cancer	HER2, HER3, MUC1, CA15-3, VEGF-A, CD44v6, CEA, ICAM-1
Colorectal Cancer	CEA, CA19-9, GPA33, CD44v6, EpCAM, MMP-9, ICAM-1
Endometrial Cancer	CA125, CEA, VEGF-A, CD44v6
Gastrointestinal Cancers	CEA, CA19-9, GPA33, PSCA, CD44v6, MUC16, ICAM-1, VEGF-A
Head and Neck Cancer	EGFR, CD44v6, VEGF-A, PD-L1, ICAM-1
Hematological Malignancies	CD19, CD20, CD22, CD38, CD138, CD123, FLT3, CCR2, CCR5, CSF1R
Liver Cancer	AFP, GPC3, HGF, VEGF-A, ICAM-1
Lymphoma (B-cell)	CD19, CD20, CD22, CD38, CD138, BAFF, APRIL
Melanoma	NY-ESO-1, STAT3, CD73, TIGIT, LAG-3
Multiple Myeloma	CD38, CD138, BAFF, APRIL, CD56
Non-Small Cell Lung Cancer (NSCLC)	EGFR, NY-ESO-1, VEGF-A, CD73, CD47, PD-L1, TIM-3, LAG-3
Ovarian Cancer	CA125, MUC16, WT1, CEA, VEGF-A
Pancreatic Cancer	CA19-9, CEA, CD73, ICAM-1
Prostate Cancer	PSA, PSMA, PCA3, VEGF-A, CD44v6
Thyroid Cancer	Thyroglobulin, Calcitonin

Tumor Marker Detection Techniques

Creative Biolabs provides an extensive portfolio of tumor marker detection products geared to the needs of the cancer field. Thanks to our advanced tissue, cell, protein, multiplex, and genomic detection systems, we can deliver unparalleled sensitivity and specificity. We use our expertise to design every solution precisely, accurately, and reliably, providing scientists with robust biomarker discovery.

Tissue-Based Detection: IHC, FISH

If you want to detect tumor markers in solid tumor tissues and localize them visually, use IHC or FISH.

Technique	Description	Advantages	Applications
Immunohistochemistry (IHC)	Uses specific antibodies to detect tumor markers in tissue sections.	- Visual and spatial analysis - Widely accessible - Enables localization of marker expression	Commonly used in pathology labs to detect markers like HER2, EGFR, and PD-L1 in solid tumors.
Fluorescence In Situ Hybridization (FISH)	Uses fluorescent probes to detect and localize specific DNA/RNA sequences within tissue samples.	- Visualizes genetic aberrations - Highly sensitive - Useful for solid tumor analysis	Commonly used to detect HER2 amplification in breast cancer and EGFR mutations in lung cancer.

Cell-Based Detection: Flow Cytometry

If you want to detect cell-surface and intracellular markers in single cells, particularly in blood cancers, use Flow Cytometry.

Technique	Description	Advantages	Applications
Flow Cytometry	Detects cell-surface and intracellular markers in single cells, enabling population analysis.	- Fast and multi-parametric - Excellent for rare cell detection - Quantitative	Widely applied in immunophenotyping and the analysis of blood cancers like lymphoma and leukemia.

Protein-Based Detection: ELISA, SMC, Mass Spectrometry

If you want to detect protein biomarkers in serum, plasma, or tissue extracts with high sensitivity and specificity, use ELISA, SMC, or Mass Spectrometry.

Technique	Description	Advantages	Applications
Enzyme-Linked Immunosorbent Assay (ELISA)	A widely used assay that utilizes antibodies to detect and quantify specific tumor markers.	- High sensitivity and specificity - Cost-effective - Rapid results	Ideal for high-throughput screening and monitoring known tumor markers like CA15-3, PSA, and CEA.
Single Molecule Counting (SMC)	Detects individual protein molecules for ultra-sensitive quantification.	- High sensitivity - Minimal sample volume needed - Detects low-abundance markers	Ideal for monitoring markers in plasma, serum, and other low-concentration samples.
Mass Spectrometry (MS)	Analyzes protein and peptide composition to identify unique tumor markers.	- High specificity - Quantitative results - Suitable for proteomic studies	Applied in identifying and validating protein biomarkers in solid and liquid samples.

Multiplex Detection: Multiplex Assay (MILLIPLEX), Luminex xMAP Technology

If you want to detect multiple biomarkers simultaneously in a single sample, saving time and resources, use Multiplex Assays (e.g., MILLIPLEX) or Luminex xMAP Technology.

Technique	Description	Advantages	Applications
Multiplex Assay (e.g., MILLIPLEX)	Allows simultaneous detection of multiple tumor markers within a single sample.	- Saves time and reduces sample volume - High data density - Excellent for studying complex biomarker interactions	Suitable for comprehensive profiling of multiple markers in cancer research.
Luminex xMAP Technology	Utilizes color-coded beads for multiplex biomarker detection in a single reaction.	- High throughput - Multi-marker detection - Precise and efficient	Suitable for biomarker discovery and validation studies in large sample sets.

Genomic Detection: NGS, ddPCR

If you want to detect DNA/RNA mutations, methylation patterns, and other genomic markers, especially for liquid biopsies and genetic profiling, use NGS or ddPCR.

Technique	Description	Advantages	Applications
Next-Generation Sequencing (NGS)	An advanced technique that sequences DNA/RNA to identify genetic mutations and methylation markers.	- High-resolution detection - Enables analysis of cfDNA and ctDNA - Capable of detecting rare mutations	Frequently used for liquid biopsies and early-stage cancer detection.
Digital Droplet PCR (ddPCR)	A digital PCR technique that quantifies low-abundance targets with high precision.	- Ultra-sensitive for detecting low-level DNA/RNA - Suitable for cfDNA and ctDNA - Accurate quantification	Ideal for detecting mutations and methylation in liquid biopsy samples for cancer diagnostics.

Workflow: Comprehensive Steps for Your Success in Tumor Marker Analysis

Our streamlined workflow at Creative Biolabs ensures a meticulous and efficient process, consistently providing you with high-quality results for your tumor marker analysis. Each stage is optimized for precision and clarity, guiding your project from conception to conclusive data:

A simple procedure for tumor marker assay. (Creative Biolabs Original)

Publication

This publication re-examines the anti-tumor mechanism of bevacizumab, a monoclonal antibody used to treat various malignancies. The paper discusses that while bevacizumab's anti-tumor activity is traditionally attributed to its anti-angiogenic properties—inhibiting the formation of new blood vessels that tumors need to grow —increasing evidence suggests it may also have a direct cytotoxic effect on tumor cells that express the vascular endothelial growth factor A (VEGFA). The authors propose a redefined framework that incorporates both its direct anti-tumor and anti-angiogenic properties. They also highlight that the effectiveness of bevacizumab may vary among patients due to differences in their tumor cells' VEGFA expression levels and that traditional in vitro methods may have overlooked the direct cytotoxic effects.

Fig.1 VEGFA-mediated crosstalk between endothelial and tumor cells. (OA Literature) Fig.1 Dual role of VEGFA signaling in endothelial activation and tumor progression.¹

Why Choose Us?

Creative Biolabs is a trusted leader in tumor marker assay development, combining cutting-edge technology with deep scientific expertise to support cancer research and diagnostics. Tumor markers—proteins or nucleic acids linked to cancer—play a vital role in early detection, diagnosis, treatment monitoring, and recurrence surveillance. Our advanced assays leverage innovations like liquid biopsy and nanotechnology, including gold nanoparticles and magnetic particles, to deliver unmatched sensitivity and specificity.

At Creative Biolabs, we go beyond data—we provide meaningful insights to accelerate your breakthroughs. Our rigorous quality control ensures accurate, reproducible results you can trust. Whether you're exploring new biomarkers or optimizing clinical applications, our tailored solutions empower your research with precision and reliability. Partner with us to advance your oncology projects with confidence, from early discovery to patient monitoring. With our expertise, you gain a competitive edge in the fast-evolving field of precision medicine.

Contact us to learn more about specific marker panels relevant to your research area.

Frequently Asked Questions

Q1: How sensitive are Creative Biolabs' tumor marker assays for early cancer detection?

A1: Our assays at Creative Biolabs are engineered for ultra-high sensitivity, often leveraging advanced technologies like next-generation sequencing (NGS), digital PCR (ddPCR), and nanomaterial-enhanced immunoassays. This allows for the detection of very low concentrations of biomarkers.

Q2: What types of samples can be used for Creative Biolabs' tumor marker assays?

A2: Creative Biolabs analyzes diverse samples for tumor marker assays - blood (serum/plasma), urine, tissue biopsies (fresh/frozen), and cell culture supernatants. We advise on optimal sample selection and collection for your project's success

Q3: What if my target tumor marker is novel or not well-characterized?

A3: Creative Biolabs develops custom assays and discovers biomarkers using advanced 'omics' platforms. Our experts identify and characterize novel targets, then create tailored assays—even for poorly characterized markers—to meet your specific research needs.

Customer Review

Enhanced Specificity for Complex Samples
Creative Biolabs' tumor marker assays, especially their exosome isolation, have greatly enhanced our pancreatic cancer diagnostics. Their technology detects biomarkers in complex samples with exceptional clarity, reducing background noise and significantly advancing our research. - Dr. Ka Pl
Accelerated Companion Diagnostic Development
The rapid and accurate detection of treatment-response biomarkers by Creative Biolabs' assays has been instrumental in accelerating our companion diagnostic development program. Their ability to quickly optimize assays for new drug targets is a significant competitive advantage. - Dr. Rt Js

Related Services

To further support your oncology research and development, Creative Biolabs offers a comprehensive suite of complementary services that can seamlessly integrate with your tumor marker assay needs:

Tumor Profiling as Diagnostic Tool

Tumor profiling is a powerful tool for gene expression profiling to identify the tissue of origin in patients with cancer of unknown primary. Molecular profiling of cancer cells is useful in diagnosis, leading to more site-specific therapy and improved patient survival.

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Intratumoral Treg Assay Service

Creative Biolabs provides a service for the comprehensive analysis and characterization of intratumoral T regulatory cells (Tregs). Utilizing advanced techniques and technologies, this service provides valuable insights into the role of Tregs in the tumor microenvironment.

Learn More →

How to Contact Us

Ready to advance your oncology research with cutting-edge tumor marker assay solutions from Creative Biolabs? Our team of highly experienced specialists is eager to discuss your specific project requirements and provide tailored solutions that meet your scientific objectives.

Contact Our Team for More Information and to Discuss Your Project

Reference

Wang, Zhiyong, et al. "Direct antitumor activity of bevacizumab: an overlooked mechanism?" Frontiers in pharmacology 15 (2024): 1394878. Distributed under Open Access license CC BY 3.0, without modification. DOI: https://doi.org/10.3389/fphar.2024.1394878

Partner with

Great Partners of Creative Biolabs. (Creative Biolabs Authorized)

Highly Reliable Assays for Cancer Research

"As a research lab focused on immuno-oncology, we needed highly reliable tumor marker assays. Creative Biolabs delivered exactly what we needed. Their customized assays for breast cancer markers were precise and provided clear, reproducible results. We are confident in their technology and look forward to future collaborations."

Precise Flow Cytometry Service

"We chose Creative Biolabs for their flow cytometry service to analyze blood cancer markers, and they exceeded our expectations. Their system was fast, and the results were accurate, providing us with the multi-parametric data needed to analyze rare cell populations effectively."

Outstanding ELISA Assay for Protein Markers

"We used Creative Biolabs' ELISA assays to monitor key protein markers in our cancer samples. The assays were sensitive and cost-effective, providing reliable quantitative data that allowed us to track tumor progression with confidence."

Effective Immunohistochemistry (IHC) Service

"Creative Biolabs' IHC service was instrumental in our research on HER2 expression in breast cancer. The staining process was clean and well-executed, and we were able to visualize the localization of tumor markers within tissue samples with ease."