Lipopolysaccharide (LPS) from Escherichia coli O113

Lipopolysaccharide (LPS) is a major structural component of the outer membrane of Gram-negative bacteria and serves as a prototypical endotoxin. This product is purified from Escherichia coli O113 by ultracentrifugation, a method that effectively removes contaminating proteins, nucleic acids, and other cellular components, yielding highly purified LPS suitable for cell biology and immunology research.
LPS exhibits a broad spectrum of biological activities, including potent activation of Toll-like receptor 4 (TLR4) signaling, induction of pro-inflammatory cytokine production, and stimulation of innate immune responses. It is widely used as a tool to model endotoxemia, study macrophage and dendritic cell activation, and investigate inflammation-related pathways.
This product is intended for research use only and is not for human or diagnostic applications.

Endotoxin testing

1 mg

High Purity: Purified by ultracentrifugation, minimizing contamination with lipoproteins, flagellin, and nucleic acids.
Well-Defined Source: Derived from E. coli O113, a strain commonly used in endotoxin research.
Broad Biological Activity: Exhibits classic endotoxin activities including TLR4 activation, cytokine induction (e.g., TNF-α, IL-6), and immune cell stimulation.
Consistent Quality: Manufactured under strict quality control; each batch is accompanied by a Certificate of Analysis.

Certificate of quality

‑20°C