Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe solubility of a drug is the maximum amount of drug dissolved in a certain amount of solvent at a certain temperature (gas at a certain pressure) and is usually expressed as a solute (1 g or 1 mL) dissolved in several milliliters of solvent. The solubility of a drug affects its pharmacokinetic properties, chemical stability, and choice of dosage form, and is an important part of the drug-based evaluation. Methods for increasing the solubility of the drug include: forming a soluble salt, introducing a hydrophilic group, adding a co-solvent, using a mixed solvent, and adding a solubilizing agent.
In recent years, researchers have developed a virtual computing algorithm that can predict the concentration-related solubility performance in the early stages, which is also based on molecular surface charge and hydrophobic interactions. Creative Biolabs can provide you with the latest assessment of drug solubility, which is conducive to the drug's drug-forming properties.
The macroscopic properties of drugs mainly include relative molecular mass, solubility, fat solubility, and polar surface area. Among them, water solubility is an important content for evaluating the drug-forming properties of drugs, and it is also a prerequisite for oral absorption, which is a necessary condition for drugs to penetrate cell membranes. Solubility data is of great importance in estimating the parameters of clinical trials such as absorption, distribution, metabolism, and excretion in the body. In recent years, with the wide application of medicinal chemistry and the development of high-throughput technology, research work in silico solubility evaluation has also grown rapidly. More than 20 methods have successfully predicted the water solubility of drugs.
Fig.1 Stimulation of in silico solubility evaluation and improvement. (Yamamoto, 2016)
In pharmaceutical development, the water solubility of a drug plays a significant role. Creative Biolabs owns innovation computer simulation technology and a high-level technology platform and equipment. If you are interested in solubility evaluation and improvement, please contact us and we will happy to help you with accurate drug solubility evaluation and transformation.
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