In the field of applying phage display technology and Magic™ sequencing technology, Creative Biolabs has accumulated extensive experiences to select good binders with high specificity and affinity from our diverse phage display libraries on our advanced phage display platform. We are pleased to share our cutting-edge technology in providing the service of inorganic molecule binding peptides identification to our customers.
The Background of Inorganic Molecules as Substrates of Phage Display
Phage display is a powerful tool for the selection of short peptide ligands with high affinity. It has been utilized for more than two decades for the identification of short peptides, which bind to the substrate of interest with high selectivity. While primarily used for the identification of ligands to proteins, the scope of targets for phage display has significantly expanded. Based on the afﬁnity selection of phage peptides libraries, more and more peptides binders that speciﬁcally bind to substrates, including natural or synthetic polymers, organic molecules, have been identified. Nowadays, phage display has also been applied to identify ligands with high affinity to a broad range of other substrates. With its rapidly expanding scope, there is more and more evidence shows that the phage display technique allows the identification of specific peptide binders to a myriad of inorganic molecules, including metal, metal borides, metal oxides, metal sulfide, magnetic materials, semiconductor, etc. These binding peptides can serve as templates to control the nucleation and growth of inorganic nanoparticles. Moreover, the integration of two different binding motifs into a single phage, which makes a bifunctional phage, could be useful for the generation of new composite materials.
Fig.1 Specificity and Biomineralization Activities of Ti-Binding Peptide-1 (Sano et al. 2005).
Small Inorganic Molecules as Substrates for Peptide Binder Identification
|Metal||Au, Ag, Pt, Pd, Ti, etc.|
|Metal borides||Ni3B, etc.|
|Metal oxides||ZnO, SiO2, TiO2, etc.|
|Metal sulfide||ZnS, CdS, etc.|
|Magnetics materials||Fe2O3, Fe3O4, etc.|
Key Advantages of Inorganic Molecule Binding Peptides Identification Service
Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs is confident in providing top-quality service based on phage display platform. Our scientists can offer high-quality inorganic molecule binding peptides identification service to meet our clients’ demands precisely. For more detailed information, please feel free to contact us or directly send us an inquiry.