Ionotropic glutamate receptors are ligand-gated ion channels involved in fast excitatory transmission in the CNS (central nervous system), which are activated by the neurotransmitter glutamate. There are four types of ionotropic glutamate receptors including AMPA receptors, delta receptors, kainite receptors, and NMDA-receptor subunits. Ionotropic glutamate receptors are formed with four subunits, called the tetramers. Each subunit has a shared architecture with four domain layers: two extracellular clamshell domains called the N-terminal domain (NTD) and ligand-binding domain (LBD; which binds glutamate), the transmembrane domain (TMD) that forms the ion channel, and an intracellular C-terminal domain (CTD). Ionotropic glutamate receptors are found throughout the brain including the hippocampus, cortical regions, basal ganglia, amygdala, midbrain, hindbrain, and brainstem nuclei.
Members of the ionotropic glutamate receptor family mediate most of the excitatory synaptic transmission throughout the CNS and play a critical role in synaptic plasticity, which is significant for learning and memory. We're concerned here with several ionotropic glutamate receptors in human that you might be interested in.
|Human Ionotropic Glutamate Receptor Members|
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