Ionotropic Glutamate Receptor Family

Ionotropic glutamate receptors are ligand-gated ion channels involved in fast excitatory transmission in the CNS (central nervous system), which are activated by the neurotransmitter glutamate. There are four types of ionotropic glutamate receptors including AMPA receptors, delta receptors, kainite receptors, and NMDA-receptor subunits. Ionotropic glutamate receptors are formed with four subunits, called the tetramers. Each subunit has a shared architecture with four domain layers: two extracellular clamshell domains called the N-terminal domain (NTD) and ligand-binding domain (LBD; which binds glutamate), the transmembrane domain (TMD) that forms the ion channel, and an intracellular C-terminal domain (CTD). Ionotropic glutamate receptors are found throughout the brain including the hippocampus, cortical regions, basal ganglia, amygdala, midbrain, hindbrain, and brainstem nuclei.

Members of the ionotropic glutamate receptor family mediate most of the excitatory synaptic transmission throughout the CNS and play a critical role in synaptic plasticity, which is significant for learning and memory. We're concerned here with several ionotropic glutamate receptors in human that you might be interested in.

By using our Magic™ membrane protein production platform, scientists in Creative Biolabs are very experienced in offering the protein preparation services of these membrane proteins mentioned above in required formats through different strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with stable cell line.

Magic™ membrane protein production platform – Creative Biolabs

Furthermore, Magic™ membrane protein antibody discovery platform in Creative Biolabs can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.

All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.

Online Inquiry

Verification code
Click image to refresh the verification code.


USA: 45-1 Ramsey Road, Shirley, NY 11967, USA
Europe: Heidenkampsweg 58, 20097 Hamburg, Germany
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us