Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsIonotropic glutamate receptors are ligand-gated ion channels involved in fast excitatory transmission in the CNS (central nervous system), which are activated by the neurotransmitter glutamate. There are four types of ionotropic glutamate receptors including AMPA receptors, delta receptors, kainite receptors, and NMDA-receptor subunits. Ionotropic glutamate receptors are formed with four subunits, called the tetramers. Each subunit has a shared architecture with four domain layers: two extracellular clamshell domains called the N-terminal domain (NTD) and ligand-binding domain (LBD; which binds glutamate), the transmembrane domain (TMD) that forms the ion channel, and an intracellular C-terminal domain (CTD). Ionotropic glutamate receptors are found throughout the brain including the hippocampus, cortical regions, basal ganglia, amygdala, midbrain, hindbrain, and brainstem nuclei.
Members of the ionotropic glutamate receptor family mediate most of the excitatory synaptic transmission throughout the CNS and play a critical role in synaptic plasticity, which is significant for learning and memory. We're concerned here with several ionotropic glutamate receptors in human that you might be interested in.
| Human Ionotropic Glutamate Receptor Members | |||||
| GRIA1 | GRIA2 | GRIA3 | GRIA4 | GRID1 | GRID2 |
| GRIK1 | GRIK2 | GRIK3 | GRIK4 | GRIK5 | GRIN1 |
| GRIN2A | GRIN2B | GRIN2C | GRIN2D | GRIN3A | GRIN3B |
By using our MemDX™ membrane protein production platform, scientists in Creative Biolabs are very experienced in offering the protein preparation services of these membrane proteins mentioned above in required formats through different strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, with stable cell line.
Furthermore, MemDX™ membrane protein antibody discovery platform in Creative Biolabs can be applied in developing antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
