Integrin alpha-V (ITGAV), which in humans is encoded by the ITGAV gene, is composed of an alpha chain and a beta chain. It binds to multiple integrin beta chains to form different integrins. In mammals ITGAV includes αVβ1, αVβ3, αVβ5, αVβ6, and αVβ8 subtypes. ITGAV is a heterodimeric integral membrane protein, which acts as a receptor for many proteins, involved in the cell signal transduction through recognition the sequence R-G-D in a wide array of ligands.
|Basic Information of ITGAV|
|Protein Name||Integrin alpha-V|
|Aliases||TGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V|
|Organism||Homo sapiens (Human)|
ITGAV is essential for a variety of cellular signaling pathways including NRG1-ERBB signaling, FGF1 signaling and IL1B signaling. In addition to mediating cell signal transduction, ITGAV also plays a crucial role in cell adhesion. Integrin forms membrane-associative adhesion complexes by recruiting adaptors and signaling proteins and finally plays a role in the classical pathway of adhesion signaling. Several diseases are associated with ITGAV, such as epithelial adhesion, proliferation, wound healing and cancer. Overexpression of the ITGAV gene has been associated with progression and spread of colorectal cancer and prostate cancer. Besides, integrin signaling is also important for the generation and maintenance of epidermis, the heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. In conclusion, integrin regulates cell growth, survival, movement and differentiation through interaction with ECM, various intramembrane and intracellular molecules.
Fig.1 Integrin intracellular signaling pathways regulated by ILK. (Shishido, 2014)
The authors proposed a new method for β3 integrin antagonists to solve the clinical problems of failed arteriovenous pathways in early hemodialysis.
This review discussed the mechanism of αvβ3 signaling in bone metastases and prostate cancer cells. Vvβ3 activated the PI-3 kinase/Akt signaling pathway, mediating adhesion and migration of prostate cancer cells to osteopontin and vitronectin to promote prostate cancer metastasis to bone.
The authors discuss the expression of αv integrin on different cell types, promoting host microenvironment angiogenesis and exogenous matrix deposition, thereby contributing to cancer progression.
The article suggested that cells altered ligand-specific changes by altering the expression of the α integrin subunit, or interacted with the extracellular matrix through integrin cytoplasmic domain, indicating the important role of integrins in development.
This article summarized the structure and function of Ad-adhesive and αv integrin receptors, investigated the structure of integrin-Ad complexes and discussed their exact role in viral infection and gene delivery.
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