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KCNC2 Membrane Protein Introduction

Introduction of KCNC2

KCNC2, also known as Kv3.2, is an integral membrane protein that belongs to the Kv3 subfamily of voltage-gated potassium channels. The Kv3 subfamily is composed of the subunits Kv3.1-3.4 that can be constructed as either homotetrameric potassium channels or heterotetrameric potassium channels. KCNC2 protein is encoded by the KCNC2 gene and contains 6 transmembrane segments (S1-S6) with a voltage-sensor in S4. It is primarily expressed in the brain.

Basic Information of KCNC2
Protein Name Potassium voltage-gated channel subfamily C member 2
Gene Name KCNC2
Aliases Kv3.2
Organism Homo sapiens (Human)
UniProt ID Q96PR1
Transmembrane Times 6
Length (aa) 638
Sequence MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL

Function of KCNC2 Membrane Protein

KCNC2 functions as a voltage-gated potassium channel that can alter its opened or closed conformations in accordance with the voltage difference across the membrane thereby controlling potassium ions pass across the membrane. The KCNC2-containing homotetramer channels mediate delayed-rectifier potassium currents which rapidly activate at high-threshold voltages and deactivate slowly. It has been revealed that KCNC2 is most present in neurons of the central nervous system (CNS) involved in the signal transmission. KCNC2 can regulate the fast action potential repolarization and continuous high-frequency firing in neurons of the CNS. KCNC2 is involved in the fire sustained trains of very brief action potentials at high-frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons. KCNC2 can produce action potential repolarization at nerve terminals to maintain the fidelity of synaptic transmission in neocortical GABAergic interneurons, which decrease the spike-evoked calcium influx and GABA neurotransmitter release. KCNC2 is involved in the spontaneous action potential firing in the suprachiasmatic nucleus to mediate circadian rhythm in a light-dependent manner.

A gene network by k-mean clustering was constructed with insulin signaling pathway enrichment. Fig.1 A gene network by k-mean clustering was constructed with insulin signaling pathway enrichment. (Hwang, 2016)

Application of KCNC2 Membrane Protein in Literature

  1. Hwang J.Y., et al. An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population. Scientific Reports. 2016, 6:33043. PubMed ID: 27623749

    The study shows that the decrease of KCNC2 is associated with improved hepatic gluconeogenesis and increased risk of obesity-mediated diabetes mellitus by endoplasmic reticulum stress.

  2. Boda E., et al. Brain expression of Kv3 subunits during development, adulthood, and aging and in a murine model of Alzheimer's disease. Journal of Molecular Neuroscience. 2012, 46(3):606-615. PubMed ID: 21912965

    The findings show the expression of all Kv3 transcripts in embryonic age in whole brain extracts. However, only Kv3.1, Kv3.2, and Kv3.4 subunits are present. These suggest a role of Kv3 channels in the developmental stage.

  3. Boddum K., et al. Kv3.1/Kv3.2 channel positive modulators enable faster activating kinetics and increase firing frequency in fast-spiking GABAergic interneurons. Neuropharmacology. 2017, 118:102-112. PubMed ID: 28242439

    The study indicates that positive modulation of Kv3.1 and Kv3.2 currents can promote the increase of firing frequency in fast-spiking GABAergic interneurons.

  4. Sato S., et al. Effect of candidate gene polymorphisms on reproductive traits in a Large White pig population. Anim Sci J. 2016, 87(12):1455-1463. PubMed ID: 27018129

    The study suggests that a KCNC2 polymorphism is significantly connected with total number of piglets born and the number of piglets born alive in second parity.

  5. Rosato-Siri M.D., et al. A novel modulator of Kv3 potassium channels regulates the firing of parvalbumin-positive cortical interneurons. J Pharmacol Exp Ther. 2015, 354(3):251-60. PubMed ID: 26085652

    The data indicate that Kv3 potassium channels play a role in the mediation of the firing phenotype of somatosensory interneurons. These suggest that Kv3 channels can be regarded as a promising therapeutic strategy for the disorders related to dysfunction of inhibitory feedback in corticolimbic circuits.

KCNC2 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-KCNC2 antibody development services.


As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

Reference

  1. Hwang J Y, et al. (2016). An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population. Scientific Reports. 6:33043.

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