Introduction of KCNH5
KCNH5, also known as potassium voltage-gated channel, subfamily H (eag-related), member 5, is encoded by KCNH5 gene. It has the evolutionary conservative function of promoting the growth and metastasis of brain tumor, depicts the downstream pathway, and reveals the functional cooperation of different potassium channels and the mechanism of regulating the volume of mitotic cells and tumor progression. Meanwhile, some studies have identified that only in the human placenta, the expression of voltage-gated potassium channels gene KCNH5 transposon-derived transcript after low methylation, which indicates KCNH5 could be a biomarker in the clinic.
|Basic Information of KCNH5|
|Protein Name||Potassium voltage-gated channel subfamily H member 5|
|Aliases||EAG2, H-EAG2, Kv10.2, hEAG2|
|Organism||Homo sapiens (Human)|
Function of KCNH5 Membrane Protein
KCNH5 is abundant in the brain and enhances cancer cell growth by controlling cell volume. The channel contains a cyclic nucleotide-binding homology (CNBH) domain and multiple calmodulin-binding motifs. KCNH5 plays a vital role in many biological functions, such as epithelial electrolyte transport, cell cycle, and proliferation. Previous studies have shown that it has high expression in several somatic cancer cell lines (including melanoma), normal adult brain and placenta, which suggest it could be involved in cell cycle regulation and tumor progression in cancer. In addition, studies have confirmed that KCNH5 is associated with epilepsy.
Fig.1 Structure of voltage-gated potassium channel.
Application of KCNH5 Membrane Protein in Literature
This article analyses the expression levels of these epilepsy-related genes (KCNA2, KCNB1, KCND2, KCNH1, KCNH5, KCNJ10, KCNMA1, KCNQ2, KCNQ3, and KCNT1) and identifies the potential mechanisms of the development of seizures and epilepsy in patients. These results show that these genes may be a target for clinical therapy.
This article reveals that antipsychotic drug thioridazine as an EAG2 channel blocker that reduces xenografted MB growth and metastasis and presents a case report of repurposing thioridazine for treating a human patient.
Authors in this group focus on the pharmacological activation of EAG2 channel. The data indicate that Ca2+ concentration may play an important role in activating the EAG2 channel when under physiological and/or pathological conditions.
This article examines the expression levels of neuronal-specific marker genes (CD133, GFAP, NF-M, MAP-2, KCNH1, KCNH5, SCN3A, and CACNA1A) in human bone marrow mesenchymal stem cells. The results suggest a higher expression of these genes may be related to the development of neurodegenerative disorders.
This article evaluates the methylate and expression of the reverse transcription protein KCNH5 in 25 melanoma cell line to determine whether the apparent genetic marker of the "placenta" is related to melanoma.
KCNH5 Preparation Options
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