Introduction of KCNH7
KCNH7 is encoded by the KCNH7 gene. It belongs to the potassium voltage-gated channel subfamily H which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. It is a member of voltage-gated potassium (Kv) channels subunit, which can regulate the neurotransmitter release, insulin secretion, epithelial electrolyte transport, and neuronal excitability. Meanwhile, recent studies have identified that KCNH7 is associated with various diseases such as bipolar spectrum disorder and hypotonia, which indicates KCNH7 could be a target for clinical therapy.
|Basic Information of KCNH7|
|Protein Name||Potassium voltage-gated channel subfamily H member 7|
|Organism||Homo sapiens (Human)|
Function of KCNH7 Membrane Protein
KCNH7 is a member of pore-forming (alpha) subunit. Previous studies have shown that it has high expression in several tissues, such as brain, testis, and liver, which suggests it could be involved in tissue regulation and progression. It has at least two transcriptional variants to encode different isotopes. In addition, studies have confirmed that KCNH7 plays an important role in the regulation of autophagy in a cancer cell model. Meanwhile, the expression of KCNH7 is a functional marker for brain activity including responses to novelty, sustained wakefulness, and sleep.
Fig.1 Structure of the potassium voltage-gated channel.
Application of KCNH7 Membrane Protein in Literature
This article analyzes the expression levels of Egr3 in regulating wakefulness and sleep in mice. The results show that Egr3 can interact with 5-HT2 receptors to further regulate cortical arousal, wakefulness, and sleep of mice.
This article reports that hERG3 plays a critical role in the regulation of autophagy in a cancer cell model. NS1643 can activate the AMPK-dependent signaling pathway to stimulate the Kv11.3 channel, which provides a novel therapeutic approach against melanoma.
Authors in this group conduct an exome sequencing to analyze the variants of 26 Amish subjects in four families with prevalent bipolar spectrum disorder. The results indicate that KCNH7 p.Arg394His could be a biomarker for ASMAD.
This article examines the SNP of 19 genes on 2q24.2q24.3 from a 9-month-old female patient with hypotonia. The data indicate that several genes are likely involved in these hypotonia, and mild dysmorphic features.
This article evaluates the expression of genes related to chicken breeding such as (AM184B, HTT, KCNH7, CDC42BPA, KCNIP4, GJA5, CBFB, and GPC6). These results suggest that mutations in those genes may contribute to the breeding programs of Jinghai Yellow Chicken.
KCNH7 Preparation Options
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