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KCNH7 Membrane Protein Introduction

Introduction of KCNH7

KCNH7 is encoded by the KCNH7 gene. It belongs to the potassium voltage-gated channel subfamily H which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. It is a member of voltage-gated potassium (Kv) channels subunit, which can regulate the neurotransmitter release, insulin secretion, epithelial electrolyte transport, and neuronal excitability. Meanwhile, recent studies have identified that KCNH7 is associated with various diseases such as bipolar spectrum disorder and hypotonia, which indicates KCNH7 could be a target for clinical therapy.

Basic Information of KCNH7
Protein Name Potassium voltage-gated channel subfamily H member 7
Gene Name KCNH7
Aliases ERG3
Organism Homo sapiens (Human)
UniProt ID Q9H252
Transmembrane Times 7
Length (aa) 1196
Sequence MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGFKFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSKCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSVHDIEGFGVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKASGLDFEETVPTSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMVTAGSEYQRPIIQLMRTSQPEASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNLTSLLKQDSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSDPGLPGK

Function of KCNH7 Membrane Protein

KCNH7 is a member of pore-forming (alpha) subunit. Previous studies have shown that it has high expression in several tissues, such as brain, testis, and liver, which suggests it could be involved in tissue regulation and progression. It has at least two transcriptional variants to encode different isotopes. In addition, studies have confirmed that KCNH7 plays an important role in the regulation of autophagy in a cancer cell model. Meanwhile, the expression of KCNH7 is a functional marker for brain activity including responses to novelty, sustained wakefulness, and sleep.

Structure of the potassium voltage-gated channel. Fig.1 Structure of the potassium voltage-gated channel.

Application of KCNH7 Membrane Protein in Literature

  1. Clegern W.C., et al. Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits. Sleep. 2016, 39(12): 2189-2199. PubMed ID: 28057087

    This article analyzes the expression levels of Egr3 in regulating wakefulness and sleep in mice. The results show that Egr3 can interact with 5-HT2 receptors to further regulate cortical arousal, wakefulness, and sleep of mice.

  2. Perez-Neut M., et al. Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma. Oncotarget. 2016, 7(16): 21991-2004. PubMed ID: 26942884

    This article reports that hERG3 plays a critical role in the regulation of autophagy in a cancer cell model. NS1643 can activate the AMPK-dependent signaling pathway to stimulate the Kv11.3 channel, which provides a novel therapeutic approach against melanoma.

  3. Strauss K.A., et al. A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder. Hum Mol Genet. 2014, 23(23): 6395-406. PubMed ID: 24986916

    Authors in this group conduct an exome sequencing to analyze the variants of 26 Amish subjects in four families with prevalent bipolar spectrum disorder. The results indicate that KCNH7 p.Arg394His could be a biomarker for ASMAD.

  4. Zhao P., et al. 2q24 deletion in a 9-month old girl with anal atresia, hearing impairment, and hypotonia. Int J Pediatr Otorhinolaryngol. 2018, 109: 96-100. PubMed ID: 29728193

    This article examines the SNP of 19 genes on 2q24.2q24.3 from a 9-month-old female patient with hypotonia. The data indicate that several genes are likely involved in these hypotonia, and mild dysmorphic features.

  5. Fan Q.C., et al. Identification of 19 loci for reproductive traits in a local Chinese chicken by genome-wide study. Genet Mol Res. 2017, 16(1): PubMed ID: 28340264

    This article evaluates the expression of genes related to chicken breeding such as (AM184B, HTT, KCNH7, CDC42BPA, KCNIP4, GJA5, CBFB, and GPC6). These results suggest that mutations in those genes may contribute to the breeding programs of Jinghai Yellow Chicken.

KCNH7 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-KCNH7 antibody development services.


As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

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