Introduction of KCNK17
KCNK17, the full name is potassium channel subfamily K member 17, also known as 2P domain potassium channel Talk-2, Acid-sensitive potassium channel protein TASK-4, TWIK-related acid-sensitive K(+) channel 4, TWIK-related alkaline pH-activated K(+) channel 2 (TALK-2). TASK-4 is a member of the acid-sensitive subfamily of tandem K+ channels. TASK-4 transcripts are widely expressed in humans and have the highest levels in the liver, lung, pancreas, placenta, aorta, and heart.
|Basic Information of KCNK17|
|Protein Name||Potassium channel subfamily K member 17|
|Aliases||2P domain potassium channel Talk-2, Acid-sensitive potassium channel protein TASK-4, TWIK-related acid-sensitive K(+) channel 4, TWIK-related alkaline pH-activated K(+) channel 2 (TALK-2)|
|Organism||Homo sapiens (Human)|
Function of KCNK17 Membrane Protein
KCNK17 generated K+ currents displaying a marked outward rectification which is lost by elevation of extracellular K+. KCNK17 is sensitive to extracellular pH, but in contrast to other TASK channels, pH sensitivity was shifted to more alkaline pH. The IC50 of KCNK17 is pH 8.8. Thus, KCNK17 synergizes with other TASK channels to modulate cell membrane potential over a wide range of extracellular pH. The KCNK17 channel is a new gene involved in progressive cardiac conduction disorder (PCCD), a disease with a wide range of unknown genetic origins.
Fig.1 TASK-4 pore homology model based on the crystal structure of TWIK-1. (Friedrich, 2014)
Application of KCNK17 Membrane Protein in Literature
The results indicated that heterodimerization of TASK1 and TALK2 conferred the ability of cells to produce multiple responses to a variety of physiological and pharmacological stimuli.
KCNK17 may play an important role in the pathogenesis of cerebral hemorrhage.
This study identified KCNK17 as a novel arrhythmia gene.
The A allele of the rs10947803 variant of KCNK17 was associated with increased risk of ischemic stroke (IS) and increased levels of KCNK17 gene expression.
The rs10947803 SNP (A allele) in KCNK17 increased the risk of cerebral hemorrhage but not ischemic stroke in the Chinese population.
KCNK17 Preparation Options
Membrane protein studies have advanced significantly over the past few years. Based on our versatile Magic™ membrane protein production platform, we could offer a series of membrane protein preparation services for worldwide customers in reconstitution forms or membrane protein mutants. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-KCNK17 antibody development services.
During the past years, Creative Biolabs has successfully generated many functional membrane proteins for our global customers. We are happy to accelerate the development of our clients’ programs with our one-stop, custom-oriented service. For more detailed information, please feel free to contact us.