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HighlightsIntroduction of KCNV1
KCNV1, potassium voltage-gated channel subfamily V member 1, is a protein that in humans is encoded by the KCNV1 gene. This potassium channel subunit cannot form functional channel by itself. It can modulate KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Common variations in KCNV1 have been reported to be associated with schizophrenia.
| Basic Information of KCNV1 | |
| Protein Name | Potassium voltage-gated channel subfamily V member 1 |
| Gene Name | KCNV1 |
| Aliases | Neuronal potassium channel alpha subunit HNKA, Voltage-gated potassium channel subunit Kv8.1 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q6PIU1 |
| Transmembrane Times | 6 |
| Length (aa) | 500 |
| Sequence | MPSSGRALLDSPLDSGSLTSLDSSVFCSEGEGEPLALGDCFTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMALMSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEMLRLKGRERASTRSSGGDDFWF |
Function of KCNV1 Membrane Protein
KCNV1 is a potassium channel which is also known as Kv8.1. It belongs to electrically silent KvS subunits and its expression is limited in the brain. This potassium channel subunit does not form functional channel by itself. It can form functional heterotetrametric Kv2/KvS channels which possess unique biophysical properties and display a more tissue-specific expression pattern, making them more desirable pharmacological and therapeutic targets. It can modulate KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. Common variations in KCNV1 have been reported to be associated with schizophrenia. Moreover, Kv8.1 plays function through its N-terminal domain by interacting with other subunits. Except for these functions, Kv8.1 can specifically inhibit Shab and Shaw channels. Furthermore, the various functions include neuronal excitability, regulating neurotransmitter release, insulin secretion, heart rate, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Fig.1 Subfamily-specific assembly into functional Kv channels (Bocksteins, 2016)
Application of KCNV1 Membrane Protein in Literature
This article shows that the different activities of Kv2 and homotetramers’ currents, and demonstrates that Kv5.1, Kv8.1 and Kv9.3 currents are inhibited differently by the channel blocker 4-AP.
This article reports that Kv subunits have different physiological roles in small DRG neurons.
This study investigates the molecular structure of KCNV1, and indicates the structural characterization and promoter analysis of human KCNV1 gene. It provides useful information in developing KCNV1 screening for epileptic disease.
This article reveals that Kv8.1 displays different channel activities under different concentrations. The S6 segment of Kv8.1 contributes to the activity modulation of Kv2 channels.
This article indicates that the association of Kv8.1 with other types of subunits is via its N-terminal domain.
KCNV1 Preparation Options
We provide custom membrane protein preparation services for worldwide customers. Leveraging by our advanced Magic™ membrane protein production platform, we are able to present target membrane protein in multiple active formats. Our professional scientists are happy to help you find an ideal method and make your project a success. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-KCNV1 antibody development services.
Creative Biolabs provides high-quality membrane protein preparation service to facilitate the development of worldwide customer’s research. During the past years, we have successfully established a powerful Magic™ membrane protein platform which enables us to provide a series of membrane protein preparation services. For more detailed information, please feel free to contact us.
Reference
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