Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsAs allowing the isolation of native antibodies with the preservation of the natural VH and VL pairing, Native™ Antibody Discovery has become attractive to sample naïve and antigen-experienced antibody repertoires generated in vivo over the last decade. Laser-capture microdissection (LCM) is an advanced and representative technique to isolate individual cells or cell compartments from most solid tissue samples of diverse species. Creative Biolabs has developed a novel LCM antibody discovery system to provide a rapid and reliable approach for high-quality antibodies generation.
How Does Laser-capture Microdissection Work?
As a new technology, LCM system is a commonly applied method of choice, whenever single cells need to be isolated from solid samples (e.g., tissue, biopsies) typically provided fixed in formalin, embedded in paraffin, or cryo-fixed. Based on optical microscopes coupled with a coaxial cutting laser and computer-assisted control, LCM system can successfully capture and extract cells in all tissue cells on the cap to procure pure populations of targeted cells from specific microscopic regions of tissue sections, which can be used for subsequent single-cell RT-PCR without damaging the enzymatic function. LCM is compatible with a variety of tissue types, cellular staining methods and tissue preservation protocols that allow selective procurement of fresh or archival specimens with the precision of 3-5 mm.
Fig.1 Schematic of Laser-capture microdissection technology.
Features of Laser-capture Microdissection
Customization Outputs of LCM-based Antibody Discovery System
1. Laser-capture microdissection can be a contact- and contamination-free method for isolating specific single cells from a wide variety of tissue samples depending on your requirements.
2. The use of LCM in combination with antibody discovery offers a rapid, versatile and rational method for the generation of high affinity and discriminative human monoclonal antibodies.
3. Our system establishes paired data library capturing native VH-VL chains, scalable to the consumer needs.
4. Our one-package service includes identifying and selecting cells, isolating and purifying RNA, single-cell cDNA synthesis, cDNA fragments amplifications and analysis, expression systems or expression-vectors (IgH, IgL) selection, expression and purification of your desired antibodies and even affinity purification of antibodies.
Emerging as one of the most user-friendly, reliable, and consistent single cell collection systems, LCM systems are perfect tools to optimize Native™ Antibody Discovery workflows under visual control for high-efficient antibody generation. Creative Biolabs can provide LCM platforms allowing for dissection of living tissue, enabling the extraction of live cells to satisfy our customers’ particular needs.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
