Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsLeucine-rich repeat-containing G-protein coupled receptors (LGRs) belong to class A G protein-coupled receptors (GPCRs) family. The LGRs have an ancient origin and can be detected in both vertebrates and invertebrates, including the ancestral phylum Cnidaria. Based on their respective phylogenetic placement and the property of their cognate ligands, LGRs can be divided into three types (A, B and C). Type A LGRs are characterized by 7–9 leucine-rich repeats (LRRs) within the LRR domain and a distinctively long hinge region to connect the LRR to the TM domain. Mammalian type A LGRs include the follicle-stimulating hormone receptor (FSHR), thyroid-stimulating hormone receptor (TSHR), and luteinizing hormone receptor (LHR), which can bind their respective glycoprotein hormones to help the receptor activation. Type B LGRs refer to LGR4-6, which were recently deorphanized as the R-spondin receptors. These receptors are evaluated to play roles in stem cell differentiation and association with cancers affecting the gut. Type C LGRs are the third subgroup represented by LGR7 and LGR8, which appeared to correlate with the known reproductive roles and tissue-specific expression of H2 relaxin and insulin-like peptide-3 (INSL3).
Here shows part of LGRs in humans including LGR4, a regulator of cell proliferation, differentiation, and stem cell homeostasis mainly through Wnt/β-catenin signaling; LGR5, a cancer stem cell marker and a downstream target in Wnt/β-catenin signaling; LGR6, a supporter for tumor development and progression through Wnt/β-catenin signaling, and is responsible for fueling the renewal of the sebaceous gland and skin.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
