Introduction of LGR6
LGR6, also known as GPCR or VTS20631, is a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily, encoded by LGR6 gene. It is highly homologous to LGR4 and LGR5 with 50% identity between each other at the amino acid level. The LGR4–6 is characterized by a large N-terminal extracellular domain (ECD) containing 17 leucine-rich repeats which are flanked by cysteine-rich sequences at both the N- and C-termini. And the 17 leucine-rich repeats are very important for the interaction with ligands.
|Basic Information of LGR6|
|Protein Name||Leucine-rich repeat-containing G-protein coupled receptor 6|
|Organism||Homo sapiens (Human)|
Function of LGR6 Membrane Protein
It has been shown that LGR6 can recover the effect of R-spondins on Wnt/β-catenin signaling when LGR4 is knocked down in HEK293T cells. Hence, LGR6 functions similarly as LGR4 and LGR5. It can also interact with R-spondins, a group of four secreted proteins (RSPO1–4) and positively promote the activation of Wnt/β-catenin signaling. LGR6 can regulate multiple biological processes via mediating Wnt/β-catenin signaling, including cell proliferation, differentiation, and apoptosis. Studies indicate that LGR6 can be regarded as an epithelial stem cell marker that can give rise to all cell lineages of the skin, including those of the hair follicle, sebaceous gland, and interfollicular dermis. Moreover, LGR6 may play a role in the pathological process of many tumors, such as colon cancer, ovary cancer, pancreas cancer. The results have shown that overexpression of wild-type LGR6 in HeLa cell could lead to an increase of cell migration and LGR6 is hypermethylated in about 50% of colon cancer.
Fig.1 RSPO augmentation of Wnt signaling. (Schindler, 2018)
Application of LGR6 Membrane Protein in Literature
The study indicates that LGR6 acts as an antiapoptosis protein which promotes the progression of gastric cancer through PI3K/AKT/mTOR pathway.
The study reports that LGR6 promotes proliferation and invasion of colorectal cancer, suggesting that LGR6 may act as a potential diagnostic and prognostic biomarker for colorectal cancer.
The authors propose that the inhibition of LGR6 can promote osteogenic differentiation of bone marrow stromal cells (BMSCs) and bone healing.
In this review, authors summarize current data about LGR5 and LGR6 in the ovarian surface epithelium (OSE) and fallopian tube epithelium (FTE). LGR5 and LGR6 are required in the process of recovery from injury and they are the key determinants of stem cell number. Besides, LGR5 and LGR6 are involved in the pathological process of cancer, suggesting LGR5 and LGR6 can act as the therapeutic targets for cancer treatment.
The findings show that LGR6 expression is enriched in cells with stem cell characteristics, and LGR6 downregulation in vivo causes increased epidermal proliferation, suggesting LGR6 is a stem cell marker in mouse skin squamous cell carcinoma.
LGR6 Preparation Options
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