Cardiolipin
Creative Biolabs is one of the leading companies that focus on lipid-based delivery technologies. We provide a variety of high-quality cardiolipin with excellent biocompatibility for the development of drug delivery systems. Liposomes containing cardiolipin have shown the advantages of improving biodistribution and reducing the toxicity of drugs.
Figure 1. General molecular formula of CL
Cardiolipin (CL) was first isolated from the beef heart in the 1940s and is found abundant in the inner mitochondrial membrane, which comprises about 20% of the total lipid composition. CL is a kind of diphosphatidylglycerol lipid characterized by a glycerol backbone connected to two phosphatidyl lipids, so each molecule has four acyl chains and potentially two negative charges. Changes in pH and the presence of divalent cations can lead to a structural change of CL due to its unique composition. For example, it is found that there is a lamellar-to-hexagonal phase transition on CL in the presence of Ca2+ or other divalent cations, which are believed to have connections with membrane fusion. Besides, research has shown that CL also plays a key role in apoptosis, oxidative phosphorylation, and cholesterol translocation, etc.
As your expert in lipid-based drug delivery, Creative Biolabs offers various kinds of lipid products, customized formulations, and liposomes development services. Please feel free to contact us to explore another world about what we can do.
For Research Use Only. Not For Clinical Use
