Liposome Preparation Kits
Products Publish Data FAQs Resources
Product Details
Liposomes are closed vesicles with a lipid bilayer structure that can encapsulate both hydrophilic and hydrophobic drugs within the vesicle interior or the lipid bilayer membrane. With extensive experience in lipid-based delivery systems, Creative Biolabs has dedicatedly developed a liposome preparation kit that streamlines the experimental process for customers. This kit serves as a convenient tool for instant liposome preparation, allowing for quick and easy formation of liposomes while preventing instability issues such as oxidation, hydrolysis, aggregation, or leakage associated with liposomes.
If you are interested in our liposome preparation kit, feel free to contact us for more information. Creative Biolabs is excited about the opportunity to partner with you in liposome research!
Publish Data
Effectiveness of a Controlled 5-FU Delivery Based on FZD10 Antibody-Conjugated Liposomes in Colorectal Cancer In vitro Models
Author: Scavo, Maria Principia, et al.
This project investigated the effects of FZD10 antibody-based 5-Fluorouracil liposomes (anti-FZD10/5-FU/LPs) on colorectal cancer (CRC) cells. Researchers successfully prepared 5-FU/LPs using a liposome preparation kit and obtained anti-FZD10/5-FU/LPs through conjugation with the FZD10 antibody. Subsequently, they assessed the impact of FZD10/5-FU/LPs with different concentrations of 5-FU on cell survival of FZD10-positive CRC cells (CoLo-205 and CaCo-2). The results indicated that, compared to free 5-FU and non-targeted liposomes (5-FU/LPs), anti-FZD10/5-FU/LPs significantly enhanced the cytotoxic activity of 5-FU in a time-dependent manner. This study demonstrates that the liposome preparation kit can effectively produce drug-loaded liposomes, which can be conjugated with antibodies for targeted delivery. By encapsulating the drug within liposomes, this kit significantly enhances its therapeutic efficacy, making it an invaluable asset in the field of treatment.
Fig.1 Impact of targeted liposomes (anti-FZD10/5-FU/LPs) on the cellular viability of FZD10-positive cells.1,2
FAQs
What solvent should I use for dissolving lipids before preparation?
We recommend using organic solvents such as chloroform or ethanol for dissolving the lipids.
Are the liposomes prepared with this kit suitable for in vitro studies?
Yes, the liposomes prepared with this kit are intended for research purposes and can be utilized in in vitro experiments.
Can the prepared liposomes be stored for future use?
The prepared liposomes can be stored at 4°C for a limited period, but we recommend using them fresh for optimal efficacy.
Are these kits suitable for preparing drug-loaded liposomes?
Yes, these kits are designed for the preparation of drug-loaded liposomes. Simply incorporate the drug during the formulation process.
What is the process for ordering the liposome preparation kit, and what is the expected delivery time?
To order the kit, please contact our customer service team for assistance with the ordering process and to inquire about the estimated delivery time.
Resources
References
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Scavo, Maria Principia, et al. "Effectiveness of a controlled 5-FU delivery based on FZD10 antibody-conjugated liposomes in colorectal cancer in vitro models." Pharmaceutics 12.7 (2020): 650.
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under Open Access license CC BY 4.0, without modification.
For Research Use Only. Not For Clinical Use
