Cholesterol increases membrane rigidity and stability, reducing the permeability of the liposomes which is crucial for protecting and delivering encapsulated drugs effectively.
They are extensively used in drug delivery systems to transport therapeutic agents with improved control over release rates, targeting cancer therapies specifically.
Yes, their biocompatibility and enhanced pharmacokinetic properties make them suitable for in vivo studies, particularly in targeted drug delivery
Preparation methods include thin-film hydration followed by processes such as extrusion or sonication, ensuring uniform size and efficient drug encapsulation.
Influence of lipophilicity of anthracyclines on the interactions with cholesterol in the model cell membranes.
This study explored the impact of anthracyclines' lipophilicity on their interaction with cholesterol in cell membranes. Researchers used DMPC:Chol liposomes with varying molar ratios (3:7 and 7:3) to mimic the biological membranes of healthy and cancer cells (with high cholesterol levels). The results revealed that daunorubicin (DNR) does not penetrate the membranes as deeply as idarubicin (IDA), which is more lipophilic and is located in both the ester group and acyl chain regions of the bilayer. It indicates that the interaction of anthracyclines with biological membranes is determined by the drug's affinity for cholesterol, which is correlates positively with its lipophilicity. Elevated cholesterol levels in cell membranes can affect drugs transport across the membrane, and this study provides insight for the preliminary screening of anti-tumor drugs with different lipophilicity.
Zaborowska, Michalina, et al. "Influence of lipophilicity of anthracyclines on the interactions with cholesterol in the model cell membranes-Langmuir monolayer and SEIRAS studies." Colloids and Surfaces B: Biointerfaces. 211 (2022): 112297. Under Open Access license CC BY 4.0, without modification.
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