DMPC:Chol Liposomes (CAT#: LDLY-0123-LY8)

Description
This product is mainly made of saturated Phosphatidylcholine (PC) and Cholesterol. PC is the most abundant phospholipid in eukaryotic cell membranes and it can form lipid bilayers. Cholesterol plays important role in liposome production. It can promote the accumulation of lipid chains and the formation of bilayers, reduce the fluidity of bilayers and the transmembrane transport of water-soluble drugs.
Lipid Composition
DMPC
Cholesterol
Applications
Control liposomes, Membrane biology
Format
Liquid
Concentration
10mg/mL
Hydration Solution
PBS, pH 7.4
External Solution
PBS, pH 7.4
Storage
2°C - 8°C (do not freeze)
Size
70-120 nm
Shelf Life
6 months
Quantity
5mL (available in lyophilized powder)
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DataSheet MSDS
FAQs Published Data Customer Reviews Related Sections
  1. What benefits do cholesterol provide in DMPC:Chol liposomes?

    Cholesterol increases membrane rigidity and stability, reducing the permeability of the liposomes which is crucial for protecting and delivering encapsulated drugs effectively.

  2. How are DMPC:Chol liposomes used in research?

    They are extensively used in drug delivery systems to transport therapeutic agents with improved control over release rates, targeting cancer therapies specifically​.

  3. Can DMPC:Chol liposomes be used for in vivo applications?

    Yes, their biocompatibility and enhanced pharmacokinetic properties make them suitable for in vivo studies, particularly in targeted drug delivery​

  4. What methods are commonly used to prepare these liposomes?

    Preparation methods include thin-film hydration followed by processes such as extrusion or sonication, ensuring uniform size and efficient drug encapsulation​.

DMPC:Chol (70:30) Liposomes-fig1


Influence of lipophilicity of anthracyclines on the interactions with cholesterol in the model cell membranes.

This study explored the impact of anthracyclines' lipophilicity on their interaction with cholesterol in cell membranes. Researchers used DMPC:Chol liposomes with varying molar ratios (3:7 and 7:3) to mimic the biological membranes of healthy and cancer cells (with high cholesterol levels). The results revealed that daunorubicin (DNR) does not penetrate the membranes as deeply as idarubicin (IDA), which is more lipophilic and is located in both the ester group and acyl chain regions of the bilayer. It indicates that the interaction of anthracyclines with biological membranes is determined by the drug's affinity for cholesterol, which is correlates positively with its lipophilicity. Elevated cholesterol levels in cell membranes can affect drugs transport across the membrane, and this study provides insight for the preliminary screening of anti-tumor drugs with different lipophilicity.

Zaborowska, Michalina, et al. "Influence of lipophilicity of anthracyclines on the interactions with cholesterol in the model cell membranes-Langmuir monolayer and SEIRAS studies." Colloids and Surfaces B: Biointerfaces. 211 (2022): 112297. Under Open Access license CC BY 4.0, without modification.

  • Enhanced Membrane Fluidity Studies
    Creative Biolabs' DMPC:Chol liposomes have significantly improved our membrane fluidity studies due to their stable bilayer structure.
  • Superior Formulation for Drug Delivery
    These liposomes provide a superior platform for encapsulating and delivering both hydrophobic and hydrophilic drugs effectively in our research.
  • Creative Biolabs' Quality Assurance
    The quality and consistency of DMPC:Chol liposomes from Creative Biolabs have been indispensable in our pharmacokinetic studies.
  • Robust Biocompatibility
    The biocompatibility of these liposomes makes them excellent for long-term studies on drug-cell interactions.
  • Creative Biolabs' Expertise in Lipid Formulations
    Relying on Creative Biolabs for their expertly formulated DMPC:Chol liposomes has greatly advanced our targeted therapy research.

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For Research Use Only. Not For Clinical Use

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