Phosphatidylserine (PS) and phosphatidylglycerol (PG) are anionic molecules that form liposomes with negative zeta potential. The zeta potential of the liposomes depending on the molar percentage of the negatively charged lipids in the liposome formulation.
Lipid Composition
DOPG DOPC
Applications
Control liposomes, Membrane biology
Format
Liquid
Concentration
10mg/mL
Hydration Solution
PBS, pH 7.4
External Solution
PBS, pH 7.4
Storage
2°C - 8°C (do not freeze)
Size
100 nm
Shelf Life
6 months
Quantity
5mL (available in lyophilized powder)
Dosage
Download
DataSheet
MSDS
FAQsPublished Data Customer ReviewsRelated Sections
What are DOPG:DOPC Liposomes?
DOPG:DOPC Liposomes are liposomes made from a mixture of DOPG and DOPC in a 90:10 molar ratio, both being unsaturated lipids.
What is the primary use of DOPG:DOPC Liposomes?
They are used as control formulations for drug-encapsulated liposome studies.
What does the zeta potential of DOPG:DOPC Liposomes indicate?
The zeta potential indicates the surface charge of the liposomes, which is negative due to the presence of anionic molecules like DOPG.
What role do DOPG:DOPC Liposomes play as control formulations?
They serve as a baseline to compare the effects of drug-encapsulated liposome formulations.
How does the molar ratio of negatively charged lipids affect DOPG:DOPC Liposomes?
The zeta potential and surface properties of the liposomes change with the molar ratio of negatively charged lipids.
The time of stochastic rupture of several single DOPG/DOPC-GUVs.
This study investigates the effect of osmotic pressure on irreversible electroporation (IRE) in giant unilamellar vesicles (GUVs). The researchers prepared GUVs with lipid compositions of DOPG/DOPC/cholesterol and DOPG/DOPC, examining the rupture of GUVs under varying osmotic pressures. In this study, DOPC:DOPG liposomes serve as the primary model system to explore the interactions between osmotic pressure and electroporation phenomena. Understanding these interactions is crucial for developing improved electroporation strategies and their applications in biotechnology and medicine.
Sarkar, Malay Kumar, et al. "Effects of osmotic pressure on the irreversible electroporation in giant lipid vesicles." PLoS One 16.5 (2021): e0251690.
Distributed under Open Access license CC BY 4.0, without modification.
Reliable Control Liposomes
These liposomes have provided reliable control for our comparative studies with drug-encapsulated liposomes.
Consistent Experimental Results
We achieved consistent and reproducible results using DOPG:DOPC Liposomes in our research.
Easy Handling and Storage
The liposomes were easy to handle and store at 4°C, ensuring long-term stability.
Reliable and Effective
The liposomes were reliable and effective for our diverse research applications.
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For Research Use Only. Not For Clinical Use 
