Lipid-Based Drug Delivery Systems in Nonalcoholic Fatty Liver Disease Treatment

Creative Biolabs offers advanced lipid-based drug delivery development platform for NAFLD. Our systems enable targeted treatment by regulating lipid metabolism, improving oxidative stress, alleviating ER stress, and reducing inflammation, providing effective solutions for your NAFLD research. Our expertise and technology can significantly accelerate your research progress in this field.

Background of Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic fatty liver disease (NAFLD), also called metabolic dysfunction-associated steatotic liver disease (MASLD), is a liver injury acquired due to metabolic stress. It's characterized by excessive lipid accumulation in hepatocytes, excluding damage from alcohol and other explicit hepatotoxins. NAFLD is closely associated with several metabolic disorders:

• Diabetes and Obesity: Type 2 diabetes and obesity are primary risk factors for NAFLD, and they often exacerbate each other.
• Cardiovascular Diseases: NAFLD can increase cardiovascular disease risk through two main pathways: (1) by releasing inflammatory mediators, thrombogenic substances, and pro - oxidants; and (2) by promoting insulin resistance and atherosclerosis.
• Disease Progression: NAFLD covers a range of liver conditions. It starts with nonalcoholic fatty liver (NAFL) and can get worse into the more serious nonalcoholic steatohepatitis (NASH). If not taken care of, NASH can lead to liver fibrosis, cirrhosis, and even hepatocellular carcinoma.

Fig. 1 The different stages of NAFLD.¹

Treatment Strategies for NAFLD

• Dietary Intervention: A balanced diet can help reduce liver fat and alleviate metabolic disorders.
• Weight Management: Weight loss through exercise is a key factor in improving the histological damage of NAFLD.
• Pharmacological Treatment: Various drugs can effectively treat NAFLD by regulating lipid metabolism, improving oxidative stress, alleviating endoplasmic reticulum stress, and reducing inflammation.
• RNA Therapy: RNA therapies offer promising avenues by modulating the expression of genes involved in lipid uptake, transport, oxidation, and secretion, thereby regulating lipid metabolism.

Fig. 2 The relevant targets for treating NAFLD.¹

How Creative Biolabs' Lipid-Based Drug Delivery Systems Can Assist Your Project

Lipid-based drug delivery systems offer numerous advantages for NAFLD treatment. They enhance drug solubility and stability, improve bioavailability, enable targeted delivery to the liver, and reduce systemic side effects. These systems can also be combined with RNA therapies for liver-targeted delivery of mRNA, siRNA, and ASO. Our systems are designed to optimize therapeutic outcomes while minimizing adverse effects, making them ideal for advancing NAFLD research.

Workflow for Lipid-Based Drug Delivery Systems Development for NAFLD

Creative Biolabs' lipid-based drug delivery systems can be utilized to achieve efficient, targeted, and safe NAFLD treatment. We provide customized delivery system development services for NAFLD, including targeted, long-circulating, and responsive release systems. We also offer a range of ready-to-use drug-loaded liposome products. These products are uniform, stable, and of high quality, helping you accelerate NAFLD treatment research. If you're interested in exploring how our systems can benefit your NAFLD research project, feel free to contact us.

Related Services

Resources

For Research Use Only. Not For Clinical Use