Introduction of LRRC38
LRRC38, Leucine-rich repeat-containing protein 38 is a protein that in humans is encoded by the LRRC38 gene. The expression is found in prostate and adrenal. This gene is conserved in chimpanzee, cow, mouse, chicken, zebrafish and frog. It has been demonstrated that 198 organisms have orthologs with human gene LRRC38. The function is displayed via leucine-rich repeats domain through participating in protein-protein interactions. It’s a gamma subunit modulator of BK alpha channel.
|Basic Information of LRRC38|
|Protein Name||Leucine-rich repeat-containing protein 38|
|Aliases||BK channel auxiliary gamma subunit LRRC38|
|Organism||Homo sapiens (Human)|
Function of LRRC38 Membrane Protein
LRRC38 (Leucine-rich repeat-containing protein 38) is a single transmembrane protein. It’s an auxiliary subunit of the large-conductance, voltage and calcium-activated potassium channel (BK alpha channel). BK channels consist of the homotetrameric pore-forming voltage and calcium-sensing α subunits (BKα), or regulatory tissue-specific auxiliary β or γ subunits. BK channel auxiliary γ (BKγ) subunits are a group of leucine-rich repeat (LRR)-containing membrane proteins, including γ1 (LRRC26), γ2 (LRRC52), γ3 (LRRC55), and γ4 (LRRC38). LRRC38 can modulate the gating characteristics by producing a marked shift in hyperpolarizing direction and in the absence of calcium. These subunits show distinct expression in different human tissues, LRRC38 is mainly expressed in secretory glands. Also, in non-excitable cells, it’s required for conversion of BK alpha channels with the state from a high-voltage to a low-voltage activated channel type. The characteristics have been identified as negative membrane voltages and constant low levels of calcium.
Fig.1 Structural features of LRRC38 (γ4) (Li, 2015)
Application of LRRC38 Membrane Protein in Literature
This article shows the molecular basis for differential modulation of BK channel by gamma subunits, and LRRC38 is gamma-4 subunit.
This article demonstrates that LRRC38 produces a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction in the absence of calcium.
This article provides comments for the article listed as reference 1, and summarizes the BK regulation, painful connections, and versatile neuropeptide signaling.
This article shows that LRRC38 can interact with BK channels to modulate the function. In non-excitable cells, it allows BK channels to an open status even at near physiological Ca2+ concentration and membrane voltage.
LRRC38 Preparation Options
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