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Magic™ Antibody Discovery - Human CD209 / DC-SIGN (59-404) Membrane Protein, Partial, His- tag (CAT#: MP1205F)

Datasheet
This membrane protein is Human CD209 / DC-SIGN (59-404). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • CD209 / DC-SIGN
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 41.3 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Gln 59 - Ala 404 (Accession # Q9NNX6-1).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • CD209 / DC-SIGN
  • Full Name
  • CD209 molecule
  • Introduction
  • This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity.
  • Alternative Names
  • CD209, CD209 molecule, CD209 antigen, CDSIGN, CLEC4L, DC SIGN, DC SIGN1, HIV gpl20-binding protein, C-type lectin domain family 4 member L, C-type lectin domain family 4, member L, dendritic cell-specific ICAM-3-grabbing non-integrin 1, dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin, DC-SIGN, DC-SIGN1, MGC129965,

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