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Magic™ Antibody Discovery - Human Coagulation Factor II / Thrombin (25-622) Membrane Protein, Partial, -His tag (CAT#: MP1314F)

Datasheet
This membrane protein is Human Coagulation Factor II / Thrombin (25-622). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • Coagulation Factor II / Thrombin
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 69.5 kDa
  • Sequence
  • AA Gln 25 - Glu 622 (Accession # AAH51332).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • Coagulation Factor II / Thrombin
  • Full Name
  • coagulation factor II, thrombin
  • Introduction
  • This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure.
  • Alternative Names
  • PT; THPH1; RPRGL2; prothrombin; prepro-coagulation factor II; prothrombin B-chain; thrombin factor II

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