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Magic™ Antibody Discovery - Human GAPDH / G3PDH (2-335) Membrane Protein, Partial, His- tag (CAT#: MP0173F)

Datasheet
This membrane protein is Human GAPDH / G3PDH (2-335). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GAPDH / G3PDH
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 36.9 kDa. The protein migrates as 37 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Gly 2 - Glu 335 (Accession # AAH01601).

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • E.coli
  • Tag
  • His tag at the N-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • GAPDH / G3PDH
  • Full Name
  • glyceraldehyde-3-phosphate dehydrogenase
  • Introduction
  • This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • G3PD; GAPD; HEL-S-162eP; glyceraldehyde-3-phosphate dehydrogenase; OCAS, p38 component; Oct1 coactivator in S phase, 38 Kd component; aging-associated gene 9 protein; epididymis secretory sperm binding protein Li 162eP; peptidyl-cysteine S-nitrosylase GAPDH

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