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Magic™ Antibody Discovery - Human GM-CSF (18-144) Membrane Protein, Partial (CAT#: MP0152F)

Datasheet
This membrane protein is Human GM-CSF (18-144). It has been tested in SDS-PAGE, BLI, Cell based assay. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GM-CSF
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 14.5 kDa. The protein migrates as 18-26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ala 18 - Glu 144 (Accession # NP_000749.2).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, BLI, Cell based assay
  • Expression Systems
  • HEK293
  • Tag
  • No tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <0.1 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • GM-CSF
  • Full Name
  • colony stimulating factor 2
  • Introduction
  • The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis.
  • Alternative Names
  • CSF, GMCSF, granulocyte-macrophage colony-stimulating factor, colony stimulating factor 2 (granulocyte-macrophage), granulocyte macrophage-colony stimulating factor, molgramostim, molgramostin, sargramostim

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