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Magic™ Antibody Discovery - Human IL-15 R alpha / CD21 (31-205) Membrane Protein, Partial, -hIgG1 Fc -Avi tag, [Biotin] (CAT#: MP0235F)

Datasheet
This membrane protein is Human IL-15 R alpha / CD21 (31-205). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-15 R alpha / CD21
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 46.6 kDa. The protein migrates as 60-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Ile 31 - Thr 205 (Accession # Q13261-1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus, followed by a Avi tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Conjugation
  • Biotin
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-15 R alpha / CD21
  • Full Name
  • Interleukin-15 receptor subunit alpha
  • Introduction
  • The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
  • Alternative Names
  • CD215, interleukin 15 receptor alpha isoform EM2, interleukin 15 receptor alpha isoform IC2, interleukin 15 receptor alpha isoform IC3, interleukin 15 receptor alpha isoform IC4, interleukin 15 receptor alpha isoform IC5, interleukin 15 receptor alpha isoform IC6, interleukin 15 receptor alpha isoform IC7, interleukin 15 receptor alpha isoform IC8, interleukin 15 receptor, alpha

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