Magic™ Antibody Discovery - Human IL-17 RA & IL-17 RC Heterodimer (33-320(IL-17RA)&21-465(IL-17RC)) Membrane Protein, Partial, -hIgG1 Fc tag & -hIgG1 Fc tag (CAT#: MP0318F)

Datasheet

This membrane protein is Human IL-17 RA & IL-17 RC Heterodimer (33-320(IL-17RA)&21-465(IL-17RC)). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

Host Species
Human

Target Protein
IL-17 RA & IL-17 RC Heterodimer

Protein Length
ECD

Molecular Weight
Calculated MW of 60.0 kDa (IL-17RA) & 75.7 kDa (IL-17RC). The reducing (R) heterodimer protein migrates as 80-90 kDa and 100-110 kDa due to glycosylation.

Sequence
AA Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC) (Accession # Q96F46-1(IL-17RA) & NP_703190.1(IL-17RC)).

Product Description

Activity
Yes

Application
SDS-PAGE, ELISA

Expression Systems
HEK293

Tag
IL-17RA is fused with a Human IgG1 Fc tag at the C-terminus. and subunit IL-17RC is fused with a Human IgG1 Fc tag at the C-terminus.

Protein Format
Soluble

Reconstitution
Please see Certificate of Analysis for specific instructions.

Endotoxin
<1.0 EU/μg by the LAL method

Purity
>95% as determined by SDS-PAGE.

Buffer
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.

Target

Target Protein
IL-17 RA & IL-17 RC Heterodimer

Full Name
interleukin 17 receptor A&interleukin 17 receptor C

Introduction
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. & This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.

Alternative Names
IL-17 RA & IL-17 RC, IL-17RA & IL-17RC, CD217 & IL-17 RC

Gene ID
23765; 84818

UniProt ID
Q96F46; Q8NAC3

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