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Magic™ Antibody Discovery - Human IL-17 RC (21-465) Membrane Protein, Partial, -hIgG1 Fc tag (CAT#: MP0322F)

Datasheet
This membrane protein is Human IL-17 RC (21-465). It has been tested in SDS-PAGE, ELISA, SEC-SEC-MALS, SPR. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-17 RC
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 75.9 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Leu 21 - Ala 465 (Accession # NP_703190.2).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SEC-SEC-MALS, SPR
  • Expression Systems
  • HEK293
  • Tag
  • Human IgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >90% as determined by SEC-MALS.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-17 RC
  • Full Name
  • interleukin 17 receptor C
  • Introduction
  • This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
  • Alternative Names
  • CANDF9; IL17RL; IL17-RL; interleukin-17 receptor C; IL-17 receptor C; IL-17RL; IL17F receptor; IL17Rhom; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; zcytoR14

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