Magic™ Antibody Discovery - Human IL-17A / CTLA-8 (24-155) Membrane Protein, Partial (CAT#: MP0302F)

Datasheet

This membrane protein is Human IL-17A / CTLA-8 (24-155). It has been tested in SDS-PAGE, ELISA, Cell based assay, SEC-SEC-MALS, BLI. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

Host Species
Human

Target Protein
IL-17A / CTLA-8

Protein Length
ECD

Molecular Weight
The protein has a calculated MW of 15.3 kDa. the protein migrates as 18 kDa under reducing (R) condition, and 28 kDa under non-reducing (NR) condition (SDS-PAGE).

Sequence
AA Gly 24 - Ala 155 (Accession # Q16552).

Product Description

Activity
Yes

Application
SDS-PAGE, ELISA, Cell based assay, SEC-SEC-MALS, BLI

Expression Systems
E.coli

Tag
No tag

Protein Format
Soluble

Reconstitution
Please see Certificate of Analysis for specific instructions.

Endotoxin
<1.0 EU/μg by the LAL method

Purity
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.

Buffer
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

Target Protein
IL-17A / CTLA-8

Full Name
interleukin 17A

Introduction
This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.

Alternative Names
IL17; CTLA8; IL-17; CTLA-8; IL-17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

Gene ID
3605

UniProt ID
Q16552

Customer reviews and Q&As Write a review Ask a question

Related Products

Online Inquiry

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: