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Magic™ Antibody Discovery - Human IL-2 R beta&IL-2 R gamma (27-239(IL-2RB)&23-254(IL-2RG)) Membrane Protein, Partial, -hIgG1 Fc tag & -hIgG1 Fc tag (CAT#: MP0878F)

Datasheet
This membrane protein is Human IL-2 R beta&IL-2 R gamma (21-236). It has been tested in SDS-PAGE, ELISA, SEC-SEC-MALS. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-2 R beta&IL-2 R gamma
  • Protein Length
  • ECD
  • Molecular Weight
  • Calculated MW of 51.1 kDa (IL-2RB) and 53.6 kDa (IL-2RG). The reducing (R) protein migrates as 65-80 kDa and 90-100 kDa respectively due to glycosylation.
  • Sequence
  • AA Ala 27 - Asp 239 (IL-2RB) & Leu 23 - Asn 254 (IL-2RG) (Accession # NP_000869.1(IL-2RB) & P31785-1(IL-2RG)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA, SEC-SEC-MALS
  • Expression Systems
  • HEK293
  • Tag
  • Subunit IL-2RB is fused with a Human IgG1 Fc tag at the C-terminus and subunit IL-2RG is fused with a Human IgG1 Fc tag at the C-terminus.
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
    >90% as determined by SEC-MALS.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-2 R beta&IL-2 R gamma
  • Full Name
  • interleukin 2 receptor subunit beta&interleukin 2 receptor subunit gamma
  • Introduction
  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. &The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
  • Alternative Names
  • IL-2 R beta & IL-2 R gamma, IL-2RB & IL-2RG

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