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Magic™ Antibody Discovery - Human IL-4 R alpha / CD124 (26-232) Membrane Protein, Partial, -His tag (CAT#: MP0873F)

Datasheet
This membrane protein is Human IL-4 R alpha / CD124 (26-232). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-4 R alpha / CD124
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 24.6 kDa. The protein migrates as 36-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Met 26 - His 232 (Accession # NP_000409.1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-4 R alpha / CD124
  • Full Name
  • interleukin 4 receptor
  • Introduction
  • This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • CD124; IL4RA; IL-4RA; interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL4R nirs variant 1; interleukin 13 receptor; interleukin-4 receptor alpha chain

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